Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum

Meiswinkel T, Lindner S, Wendisch VF (2014)
Journal of Biotechnology & Biomaterials 4(1): 167.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Thick juice (also regarded as syrup) is an intermediate product of sugar processing. It is cheaper than processed sugar and is mainly composed of sucrose. Sucrose is a preferred carbon source of Corynebacterium glutamicum, a workhorse of biotechnology used for million-ton-scale amino acid production. Here, it is shown for C. glutamicum that sugar beet thick juice led to higher growth rates and faster carbon source consumption than pure sucrose. Comparative DNA microarray analysis revealed differential expression of genes for butyrate and citrate catabolism and of NAD and biotin biosynthesis suggesting provision of these compounds by the thick juice. Thick juice was also shown to be superior to sucrose in production of the amino acids L-lysine, L-glutamate and L-arginine as well as of the diamine putrescine since higher volumetric productivities than with pure sucrose could be achieved. Taken together, sugar beet thick juice was shown to be a carbon source for growth and amino acid and diamine production of C. glutamicum superior to pure sucrose.
Erscheinungsjahr
2014
Zeitschriftentitel
Journal of Biotechnology & Biomaterials
Band
4
Ausgabe
1
Art.-Nr.
167
eISSN
2155-952X
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2704479

Zitieren

Meiswinkel T, Lindner S, Wendisch VF. Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum. Journal of Biotechnology & Biomaterials. 2014;4(1): 167.
Meiswinkel, T., Lindner, S., & Wendisch, V. F. (2014). Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum. Journal of Biotechnology & Biomaterials, 4(1), 167. doi:10.4172/2155-952X.1000167
Meiswinkel, Tobias, Lindner, Steffen, and Wendisch, Volker F. 2014. “Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum”. Journal of Biotechnology & Biomaterials 4 (1): 167.
Meiswinkel, T., Lindner, S., and Wendisch, V. F. (2014). Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum. Journal of Biotechnology & Biomaterials 4:167.
Meiswinkel, T., Lindner, S., & Wendisch, V.F., 2014. Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum. Journal of Biotechnology & Biomaterials, 4(1): 167.
T. Meiswinkel, S. Lindner, and V.F. Wendisch, “Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum”, Journal of Biotechnology & Biomaterials, vol. 4, 2014, : 167.
Meiswinkel, T., Lindner, S., Wendisch, V.F.: Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum. Journal of Biotechnology & Biomaterials. 4, : 167 (2014).
Meiswinkel, Tobias, Lindner, Steffen, and Wendisch, Volker F. “Thick Juice-Based Production of Amino Acids and Putrescine by Corynebacterium glutamicum”. Journal of Biotechnology & Biomaterials 4.1 (2014): 167.
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2019-09-06T09:18:28Z
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