Cytotoxic Compounds from Aloe megalacantha
Abdissa Ayana N, Gohlke S, Frese M, Sewald N (2017)
Molecules 22(7): 1136.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Abstract / Bemerkung
Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.
Stichworte
Asphodelaceae;
Aloe megalacantha;
roots;
quinone;
anthraquinone;
cytotoxicity
Erscheinungsjahr
2017
Zeitschriftentitel
Molecules
Band
22
Ausgabe
7
Art.-Nr.
1136
Urheberrecht / Lizenzen
ISSN
1420-3049
Page URI
https://pub.uni-bielefeld.de/record/2912699
Zitieren
Abdissa Ayana N, Gohlke S, Frese M, Sewald N. Cytotoxic Compounds from Aloe megalacantha. Molecules. 2017;22(7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., & Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7), 1136. doi:10.3390/molecules22071136
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. 2017. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22 (7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., and Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules 22:1136.
Abdissa Ayana, N., et al., 2017. Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7): 1136.
N. Abdissa Ayana, et al., “Cytotoxic Compounds from Aloe megalacantha”, Molecules, vol. 22, 2017, : 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., Sewald, N.: Cytotoxic Compounds from Aloe megalacantha. Molecules. 22, : 1136 (2017).
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22.7 (2017): 1136.
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5 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice.
Hintsa G, Sibhat GG, Karim A., Evid Based Complement Alternat Med 2019(), 2019
PMID: 31110551
Hintsa G, Sibhat GG, Karim A., Evid Based Complement Alternat Med 2019(), 2019
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Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model.
Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W., Evid Based Complement Alternat Med 2019(), 2019
PMID: 31178917
Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W., Evid Based Complement Alternat Med 2019(), 2019
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Bioactive secondary metabolites from new endophytic fungus Curvularia. sp isolated from Rauwolfia macrophylla.
Kaaniche F, Hamed A, Abdel-Razek AS, Wibberg D, Abdissa N, El Euch IZ, Allouche N, Mellouli L, Shaaban M, Sewald N., PLoS One 14(6), 2019
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Kaaniche F, Hamed A, Abdel-Razek AS, Wibberg D, Abdissa N, El Euch IZ, Allouche N, Mellouli L, Shaaban M, Sewald N., PLoS One 14(6), 2019
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Salehi B, Albayrak S, Antolak H, Kręgiel D, Pawlikowska E, Sharifi-Rad M, Uprety Y, Tsouh Fokou PV, Yousef Z, Amiruddin Zakaria Z, Varoni EM, Sharopov F, Martins N, Iriti M, Sharifi-Rad J., Int J Mol Sci 19(9), 2018
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