Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

Kouam A, Bissoue A, Tcho A, Happi E, Waffo A, Sewald N, Wansi J (2018)
Molecules 23(1): 13.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Kouam, Ariane; Bissoue, Achille; Tcho, Alain; Happi, Emmanuel; Waffo, Alain; Sewald, NorbertUniBi ; Wansi, Jean
Abstract / Bemerkung
Three new prenylated furoquinoline alkaloids named lecomtequinoline A (1), B (2), and C (3), together with the known compounds anhydroevoxine (4), evoxine (5), dictamnine (6), N-methylflindersine (7), evoxanthine (8), hesperidin, lupeol, β-sitosterol, stigmasterol, β-sitosterol-3-O-β-d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana. The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1–16.5 and 10.2–20.5 µg/mL, respectively, against Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus, and Staphylococcus warneri, while compounds 1–6 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo
Stichworte
Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C
Erscheinungsjahr
2018
Zeitschriftentitel
Molecules
Band
23
Ausgabe
1
Art.-Nr.
13
ISSN
1420-3049
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2917253

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Kouam A, Bissoue A, Tcho A, et al. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2018;23(1): 13.
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., & Wansi, J. (2018). Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules, 23(1), 13. doi:10.3390/molecules23010013
Kouam, Ariane, Bissoue, Achille, Tcho, Alain, Happi, Emmanuel, Waffo, Alain, Sewald, Norbert, and Wansi, Jean. 2018. “Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)”. Molecules 23 (1): 13.
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., and Wansi, J. (2018). Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules 23:13.
Kouam, A., et al., 2018. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules, 23(1): 13.
A. Kouam, et al., “Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)”, Molecules, vol. 23, 2018, : 13.
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., Wansi, J.: Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 23, : 13 (2018).
Kouam, Ariane, Bissoue, Achille, Tcho, Alain, Happi, Emmanuel, Waffo, Alain, Sewald, Norbert, and Wansi, Jean. “Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)”. Molecules 23.1 (2018): 13.
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2019-09-06T09:18:56Z
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24 References

Daten bereitgestellt von Europe PubMed Central.

Taxonomie des Rutaceae-Toddalieae du Cameroun revisitée: Découverte de quatre espèces nouvelles, validation d’une combinaison nouvelle et véritable identité de deux autres espèces de Vepris Comm. ex A. Juss
Onana J.M., Chevillotte H.., 2015
A review on chemistry of some species of genus Vepris (Rutaceae family)
Imbenzi P.S., Osoro E.K., Aboud N.S., Ombito J.O., Cheplogoi P.K.., 2014
Veprisine and N-methylpreskimmianine: Novel 2-quinolones from Vepris louisii
Ayafor J.F., Sondengam B.L., Ngadjui B.T.., 1980
Veprisinium salt, a novel antibacterial quaternary alkaloid from Vepris louisii.
Ayafor JF, Sondengam BL, Ngadjui BT., Planta Med. 44(3), 1982
PMID: 7089095
Veprisilone, a prenylated 2-quinolone, and limonin from Vepris louisii
Ayafor J.F., Sondengam B.L., Ngadjui B.T.., 1982
Furoquinoline and pyrano-2-quinolone alkaloids of Vepris stolzii
Khalid S.A., Waterman P.G.., 1982
Pyranoquinolones and acridones from Vepris bilocularis
Brader G., Bacher M., Greger H., Hofer O.., 1996
Acridones of Vepris sclerophylla: Their C-NMR data
Rasoanaivo P., Federici E., Palazzino G., Galeffi C.., 1999
New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest.
Prakash Chaturvedula VS, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG., J. Nat. Prod. 66(4), 2003
PMID: 12713408
An azole, an amide and a limonoid from Vepris uguenensis (Rutaceae).
Cheplogoi PK, Mulholland DA, Coombes PH, Randrianarivelojosia M., Phytochemistry 69(6), 2008
PMID: 18267321
Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity.
Kiplimo JJ, Shahidul Islam M, Koorbanally NA., Phytochemistry 83(), 2012
PMID: 22898386
Antibacterial activity of an epoxidised prenylated cinnamaldehdye derivative from Vepris glomerata
Kiplimo J.J., Koorbanally N.A.., 2012
Acridone alkaloids from Vepris verdoorniana (Excell & Mendonça) Mziray (Rutaceae)
Atangana A.F., Toze F.A.A., Langat M.K., Happi E.N., Mbaze L.L.M., Mulholland D.A.., 2017
Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem).
Akihisa T, Noto T, Takahashi A, Fujita Y, Banno N, Tokuda H, Koike K, Suzuki T, Yasukawa K, Kimura Y., J Oleo Sci 58(11), 2009
PMID: 19844073
Isolation and 2D NMR Studies of Alkaloids from Comptonella sessilifoliola1.
Pusset J, Lopez JL, Pais M, Neirabeyeh MA, Veillon JM., Planta Med. 57(2), 1991
PMID: 17226139
5-Hydroxydictamnine, a new alkaloid from Atalantia monophylla.
Kumar TS, Krupadanam GL, Kumar KA., Nat. Prod. Res. 24(16), 2010
PMID: 20835951
Alkaloids from the stem bark of Micromelum falcatum.
Luo XM, Qi SH, Yin H, Gao CH, Zhang S., Chem. Pharm. Bull. 57(6), 2009
PMID: 19483341
Acridone alkaloids and coumarins from the stem bark of Citropsis articulata (Rutaceae)
Meva´a L.M., Songue J.L., Wansi J.D., Waffo A.F.K., Dongo E., Mpondo T.N., Sewald N.., 2010
Nkolbisine, a new furoquinoline alkaloid, and 7-deacetylazadirone from Teclea verdoorniana
Ayafor J.F., Okogun J.I.., 1982
Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
Wansi JD, Mesaik MA, Chiozem DD, Devkota KP, Gaboriaud-Kolar N, Lallemand MC, Wandji J, Choudhary MI, Sewald N., J. Nat. Prod. 71(11), 2008
PMID: 18950230
Biological investigations into Antidesma madagascariense Lam. (Euphorbiaceae), Faujasiopsis flexuosa (Lam.) C. Jeffrey (Asteraceae), Toddalia asiatica (L.) Lam. and Vepris lanceolata (Lam.) G. Don (Rutaceae)
Narod F.B., Gurib-Fakim A., Anwar H.S.., 2004
New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest.
Prakash Chaturvedula VS, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG., J. Nat. Prod. 66(4), 2003
PMID: 12713408

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