Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves

Lüningschrör P, Slotta C, Heimann P, Briese M, Weikert U, Massih B, Appenzeller S, Sendtner M, Kaltschmidt C, Kaltschmidt B (2020)
Frontiers in Cellular Neuroscience 14: 185.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 8.56 MB
Autor*in
Lüningschrör, Patrick; Slotta, Carsten; Heimann, Peter; Briese, Michael; Weikert, Ulrich; Massih, Bita; Appenzeller, Silke; Sendtner, Michael; Kaltschmidt, ChristianUniBi; Kaltschmidt, BarbaraUniBi
Abstract / Bemerkung
Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous system (PNS), myelin can be degraded in an autophagy-dependent manner directly by Schwann cells or by macrophages, which are modulated by T-lymphocytes. Here, we show that the NF-κB activator Pleckstrin homology containing family member 5 (Plekhg5) is involved in the regulation of both Schwann cell autophagy and recruitment of T-lymphocytes in peripheral nerves during motoneuron disease. Plekhg5-deficient mice show defective axon/Schwann cell units characterized by myelin infoldings in peripheral nerves. Even at late stages, Plekhg5-deficient mice do not show any signs of demyelination and inflammation. Using RNAseq, we identified a transcriptional signature for an impaired immune response in sciatic nerves, which manifested in a reduced number of CD4+ and CD8+ T-cells. These findings identify Plekhg5 as a promising target to impede myelin breakdown in demyelinating PNS disorders.
Stichworte
Cellular and Molecular Neuroscience
Erscheinungsjahr
2020
Zeitschriftentitel
Frontiers in Cellular Neuroscience
Band
14
Art.-Nr.
185
ISSN
1662-5102
Page URI
https://pub.uni-bielefeld.de/record/2945109

Zitieren

Lüningschrör P, Slotta C, Heimann P, et al. Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. Frontiers in Cellular Neuroscience. 2020;14: 185.
Lüningschrör, P., Slotta, C., Heimann, P., Briese, M., Weikert, U., Massih, B., Appenzeller, S., et al. (2020). Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. Frontiers in Cellular Neuroscience, 14, 185. doi:10.3389/fncel.2020.00185
Lüningschrör, Patrick, Slotta, Carsten, Heimann, Peter, Briese, Michael, Weikert, Ulrich, Massih, Bita, Appenzeller, Silke, Sendtner, Michael, Kaltschmidt, Christian, and Kaltschmidt, Barbara. 2020. “Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves”. Frontiers in Cellular Neuroscience 14: 185.
Lüningschrör, P., Slotta, C., Heimann, P., Briese, M., Weikert, U., Massih, B., Appenzeller, S., Sendtner, M., Kaltschmidt, C., and Kaltschmidt, B. (2020). Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. Frontiers in Cellular Neuroscience 14:185.
Lüningschrör, P., et al., 2020. Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. Frontiers in Cellular Neuroscience, 14: 185.
P. Lüningschrör, et al., “Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves”, Frontiers in Cellular Neuroscience, vol. 14, 2020, : 185.
Lüningschrör, P., Slotta, C., Heimann, P., Briese, M., Weikert, U., Massih, B., Appenzeller, S., Sendtner, M., Kaltschmidt, C., Kaltschmidt, B.: Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. Frontiers in Cellular Neuroscience. 14, : 185 (2020).
Lüningschrör, Patrick, Slotta, Carsten, Heimann, Peter, Briese, Michael, Weikert, Ulrich, Massih, Bita, Appenzeller, Silke, Sendtner, Michael, Kaltschmidt, Christian, and Kaltschmidt, Barbara. “Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves”. Frontiers in Cellular Neuroscience 14 (2020): 185.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2020-08-03T15:20:58Z
MD5 Prüfsumme
bf8e8126881df4f927d756427ea1861b


Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 32733205
PubMed | Europe PMC

Suchen in

Google Scholar