Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM
Dargel C, Gräbitz-Bräuer F, Geisler R, Fandrich P, Hannappel Y, Porcar L, Hellweg T (2021)
Molecules 26(16): 4959.
Zeitschriftenaufsatz
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Autor*in
Dargel, CarinaUniBi;
Gräbitz-Bräuer, FriederikeUniBi;
Geisler, Ramsia;
Fandrich, PascalUniBi;
Hannappel, YvonneUniBi;
Porcar, Lionel;
Hellweg, ThomasUniBi 
Abstract / Bemerkung
Phosphatidylglycerols represent a large share of the lipids in the plasmamembrane of procaryotes. Therefore, this study investigates the role of charged lipids in the plasma membrane with respect to the interaction of the antiviral saponin glycyrrhizin with such membranes. Glycyrrhizin is a natural triterpenic-based surfactant found in licorice. Vesicles made of 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1’-glycerol) (DOPG)/glycyrrhizin are characterized by small-angle scattering with neutrons and X-rays (SANS and SAXS). Small-angle scattering data are first evaluated by the model-independent modified Kratky–Porod method and afterwards fitted by a model describing the shape of small unilamellar vesicles (SUV) with an internal head-tail contrast. Complete miscibility of DOPG and glycyrrhizin was revealed even at a ratio of lipid:saponin of 1:1. Additional information about the chain-chain correlation distance of the lipid/saponin mixtures in the SUV structures is obtained from wide-angle X-ray scattering (WAXS).
Stichworte
DOPG;
glycyrrhizin;
small unilamellar vesicle (SUV);
SAXS and SANS;
WAX
Erscheinungsjahr
2021
Zeitschriftentitel
Molecules
Band
26
Ausgabe
16
Art.-Nr.
4959
Urheberrecht / Lizenzen
eISSN
1420-3049
Page URI
https://pub.uni-bielefeld.de/record/2956779
Zitieren
Dargel C, Gräbitz-Bräuer F, Geisler R, et al. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules. 2021;26(16): 4959.
Dargel, C., Gräbitz-Bräuer, F., Geisler, R., Fandrich, P., Hannappel, Y., Porcar, L., & Hellweg, T. (2021). Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules, 26(16), 4959. https://doi.org/10.3390/molecules26164959
Dargel, Carina, Gräbitz-Bräuer, Friederike, Geisler, Ramsia, Fandrich, Pascal, Hannappel, Yvonne, Porcar, Lionel, and Hellweg, Thomas. 2021. “Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM”. Molecules 26 (16): 4959.
Dargel, C., Gräbitz-Bräuer, F., Geisler, R., Fandrich, P., Hannappel, Y., Porcar, L., and Hellweg, T. (2021). Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules 26:4959.
Dargel, C., et al., 2021. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules, 26(16): 4959.
C. Dargel, et al., “Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM”, Molecules, vol. 26, 2021, : 4959.
Dargel, C., Gräbitz-Bräuer, F., Geisler, R., Fandrich, P., Hannappel, Y., Porcar, L., Hellweg, T.: Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules. 26, : 4959 (2021).
Dargel, Carina, Gräbitz-Bräuer, Friederike, Geisler, Ramsia, Fandrich, Pascal, Hannappel, Yvonne, Porcar, Lionel, and Hellweg, Thomas. “Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM”. Molecules 26.16 (2021): 4959.
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