- AutorIn
- N. Kaymaz
- M. Drukker
- Roselind Lieb
- Hans-Ulrich Wittchen
- N. Werbeloff
- M. Weiser
- T. Lataster
- J. van Os
- Titel
- Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-117329
- Quellenangabe
- Psychological Medicine, Bd. 42 (2012), Nr. 11, S. 2239-2253, ISSN: 0033-2917
- Erstveröffentlichung
- 2012
- Abstract (EN)
- Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. Method A systematic review and meta-analysis was conducted of representative, longitudinal population-based cohorts with baseline assessment of subthreshold psychotic experiences and follow-up assessment of psychotic and non-psychotic clinical outcomes. Results Six cohorts were identified with a 3–24-year follow-up of baseline subthreshold self-reported psychotic experiences. The yearly risk of conversion to a clinical psychotic outcome in exposed individuals (0.56%) was 3.5 times higher than for individuals without psychotic experiences (0.16%) and there was meta-analytic evidence of dose–response with severity/persistence of psychotic experiences. Individual studies also suggest a role for motivational impairment and social dysfunction. The evidence for conversion to non-psychotic outcome was weaker, although findings were similar in direction. Conclusions Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence. These data can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk, for whom much higher transition rates have been indicated.
- Andere Ausgabe
- DOI: 10.1017/S0033291711002911
- Link zur Originalpublikation in Psychological Medicine, Cambridge University Press. Copyright © Cambridge University Press 2012
Link: http://dx.doi.org/10.1017/S0033291711002911 - Freie Schlagwörter (DE)
- Wahnvorstellungen, Halluzinationen, Meta-Analyse, Prävention, psychotische Störungen, Risiko
- Freie Schlagwörter (EN)
- Delusions, hallucinations, meta-analysis, prevention, psychotic disorders, risk
- Klassifikation (DDC)
- 150
- Klassifikation (RVK)
- CU 3000
- Publizierende Institution
- Technische Universität Dresden, Dresden
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-117329
- Veröffentlichungsdatum Qucosa
- 02.07.2013
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis