- AutorIn
- Anne Götz
- Rolf Jessberger
- Titel
- Dendritic Cell Podosome Dynamics Does Not Depend on the F-actin Regulator SWAP-70
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-127216
- Quellenangabe
- PLOS ONE, Bd. 8 (2013), Nr. 3, e60642, ISSN: 1932-6203
- Erstveröffentlichung
- 2013
- Abstract (EN)
- In addition to classical adhesion structures like filopodia or focal adhesions, dendritic cells similar to macrophages and osteoclasts assemble highly dynamic F-actin structures called podosomes. They are involved in cellular processes such as extracellular matrix degradation, bone resorption by osteoclasts, and trans-cellular diapedesis of lymphocytes. Besides adhesion and migration, podosomes enable dendritic cells to degrade connective tissue by matrix metalloproteinases. SWAP-70 interacts with RhoGTPases and F-actin and regulates migration of dendritic cells. SWAP-70 deficient osteoclasts are impaired in F-actin-ring formation and bone resorption. In the present study, we demonstrate that SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells. Furthermore, we found that toll-like receptor 4 ligand induced podosome disassembly and podosome-mediated matrix degradation is not affected by SWAP-70 in dendritic cells. Thus, podosome formation and function in dendritic cells is independent of SWAP-70.
- Andere Ausgabe
- DOI: 10.1371/journal.pone.0060642
- Link zur Originalpublikation in der Zeitschrift PLOS ONE.
Link: http://dx.doi.org/10.1371/journal.pone.0060642 - Freie Schlagwörter (DE)
- F-Aktin, Podosome, Immunsystem, TU Dresden, Publikationsfonds
- Freie Schlagwörter (EN)
- F-actin, podosomes, immune system, Actins, Bone resorption, Cell migration, Cell staining, Dendritic cells, Extracellular matrix, Fluorescence recovery, after photobleaching, Technical University Dresden, Publication funds
- Klassifikation (DDC)
- 610
- Klassifikation (RVK)
- XA 10000
- Verlag
- Public Library of Science, San Francisco, USA
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-127216
- Veröffentlichungsdatum Qucosa
- 22.01.2014
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 2.5