- AutorIn
- Michael Fröhner
- Albrecht Scholz
- Rainer Koch
- Oliver W. Hakenberg
- Gustavo B. Baretton
- Manfred P. Wirth
- Titel
- Competing Mortality Contributes to Excess Mortality in Patients with Poor-Risk Lymph Node-Positive Prostate Cancer Treated with Radical Prostatectomy
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-133747
- Quellenangabe
- Urol Int 2012;89:148–154, ISSN: 0042-1138
- Erstveröffentlichung
- 2012
- Abstract (DE)
- Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
- Abstract (EN)
- Background: Factors predicting survival in men with lymph node-positive prostate cancer are still poorly defined. Patients and Methods: 193 prostate cancer patients with histopathologically proven lymph node involvement with a median follow-up of 7.3 years were studied. 94% of patients received immediate hormonal therapy. Kaplan-Meier curves were calculated to evaluate overall survival rates and compared with the log-rank test. Cumulative disease-specific and competing mortality rates were calculated by competing risk analysis and compared with the Pepe-Mori test. Cox proportional hazard models were used to determine the independent significance of predictors of all-cause mortality. Results: Age (70 years or older vs. younger), Gleason score (8–10 vs. 7 or lower) and the number of involved nodes (3 or more vs. 1–2) were identified as independent predictors of all-cause mortality. When patients with 0–1 of these risk factors were compared with those with 2–3 risk factors, all-cause (rates after 10 years 21% vs. 71%, p < 0.0001), disease-specific (12 vs. 37%, p = 0.009) and competing mortality (9 vs. 33%, p = 0.02) differed significantly. Conclusions: Some of the excess mortality in patients with poor-risk lymph node-positive prostate cancer may be attributed to increased competing mortality, possibly caused by an interaction between comorbid diseases and hormonally treated persistent or progressive prostate cancer.
- Andere Ausgabe
- DOI: 10.1159/000339279
- Volltext des Artikels, der zuerst in der Zeitschrift "Urologia Internationalis" des Karger-Verlages erschienen ist.
Link: http://dx.doi.org/10.1159/000339279 - Freie Schlagwörter (DE)
- urologische Neoplasien, Prostatakrebs, Lymphknoten, radikale Prostatektomie, prognostische Faktoren, Überlebensrate, krankheitsspezifisches Überleben, Mortalität
- Freie Schlagwörter (EN)
- Urological neoplasms, Prostate cancer, Lymph nodes, Radical prostatectomy, Prognostic factors, Overall survival, Disease-specific survival, Competing mortality
- Klassifikation (DDC)
- 610
- Klassifikation (RVK)
- XA 10000
- Verlag
- Karger, Basel
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-133747
- Veröffentlichungsdatum Qucosa
- 14.02.2014
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis