- AutorIn
- Michael Meurer
- Manige Fartasch
- Gisela Albrecht
- Thomas Vogt
- Margitta Worm
- Thomas Ruzicka
- Peter Josef Altmeyer
- Dirk Schneider
- Gottfried Weidinger
- Matthias Bräutigam
- Titel
- Long-Term Efficacy and Safety of Pimecrolimus Cream 1% in Adults with Moderate Atopic Dermatitis
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-135560
- Quellenangabe
- Dermatology 2004;208:365–372, ISSN: 1018-8665
- Erstveröffentlichung
- 2004
- Abstract (DE)
- Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
- Abstract (EN)
- Background: Pimecrolimus cream 1% is a non-steroid, selective inflammatory cytokine inhibitor indicated for atopic dermatitis (AD). Objective: To compare the safety and efficacy of pimecrolimus cream 1%-based treatment versus conventional therapy in adults with moderate AD. Methods: Patients were randomized to receive pimecrolimus cream 1% (n = 62) or vehicle (n = 68) at the first signs/symptoms of AD, for 24 weeks as required. A moderately potent topical corticosteroid (prednicarbate 0.25% cream) was allowed in both groups to treat flares. Results: Corticosteroids were required on fewer days in the pimecrolimus group, compared with the vehicle group (9.7 vs. 37.8%, p < 0.001). Furthermore, 59.7% of pimecrolimus-treated patients experienced no flares during the study period, compared with 22.1% of vehicle-treated patients (p < 0.001). Pimecrolimus cream 1% was well tolerated throughout the study. Conclusion: For adults with moderate AD, pimecrolimus cream 1% is well tolerated, reduces the incidence of flares, reduces/eliminates corticosteroid use, improves long-term disease control and enhances the patients’ quality of life.
- Andere Ausgabe
- DOI: 10.1159/000078462
- Volltext des Artikels, der zuerst in der Zeitschrift "Dermatology" des Karger-Verlages erschienen ist.
Link: http://dx.doi.org/10.1159/000078462 - Freie Schlagwörter (DE)
- Ekzem, langfristige Behandlung, Atopische Dermatitis, topische Corticosteroide, Pimecrolimus, atopisches Ekzem
- Freie Schlagwörter (EN)
- Pimecrolimus cream 1%, Elidel, Atopic dermatitis, moderate disease, Eczema, Long-term management, Topical corticosteroids
- Klassifikation (DDC)
- 610
- Klassifikation (RVK)
- XA 10000
- Verlag
- Karger, Basel
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-135560
- Veröffentlichungsdatum Qucosa
- 28.02.2014
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis