- AutorIn
- Florian Neumann
- Titel
- Einfluss von Geschlechtshormonen auf die Volumenregulation von Müllerzellen
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-105967
- Datum der Einreichung
- 29.08.2012
- Datum der Verteidigung
- 24.01.2013
- Abstract (EN)
- Osmotic swelling of glial cells may contribute to the development of retinal edema. We investigated whether sex steroids inhibit the swelling of glial somata in acutely isolated retinal slices and glial cells of the rat. Superfusion of retinal slices or cells from control animals with a hypoosmolar solution did not induce glial swelling, whereas glial swelling was observed in slices of postis- chemic and diabetic retinas. Progesterone, testosterone, estriol, and 17ß-estradiol prevented glial swelling with half-maximal effects at approximately 0.3, 0.6, 6, and 20 lM, respectively. The effect of progesterone was apparently mediated by transactivation of metabotropic glutamate receptors, P2Y1, and adenosine A1 receptors. The data suggest that sex steroids may inhibit cytotoxic edema in the retina.
- Freie Schlagwörter (DE)
- Progesteron, 17ß-Estradiol, Diabetes, Ischämie, Glia
- Freie Schlagwörter (EN)
- Progesterone, 17ß-Estradiol, Diabetes, Ischemia, Glia
- Klassifikation (DDC)
- 610
- GutachterIn
- Prof. Dr. Andreas Reichenbach
- Den akademischen Grad verleihende / prüfende Institution
- Universität Leipzig, Leipzig
- Förder- / Projektangaben
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-105967
- Veröffentlichungsdatum Qucosa
- 21.02.2013
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Deutsch