- AutorIn
- Virginia Conde Ruiz
- Titel
- The role of network interactions in timing-dependent plasticity within the human motor cortex induced by paired associative stimulation
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-129770
- Datum der Einreichung
- 22.04.2013
- Datum der Verteidigung
- 07.11.2013
- Abstract (EN)
- Spike timing-dependent plasticity (STDP) has been suggested as one of the key mechanism underlying learning and memory. Due to its importance, timing-dependent plasticity studies have been approached in the living human brain by means of non-invasive brain stimulation (NIBS) protocols such as paired associative stimulation (PAS). However, contrary to STDP studies at a cellular level, functional plasticity induction in the human brain implies the interaction among target cortical networks and investigates plasticity mechanisms at a systems level. This thesis comprises of two independent studies that aim at understanding the importance of considering broad cortical networks when predicting the outcome of timing-dependent associative plasticity induction in the human brain. In the first study we developed a new protocol (ipsilateral PAS (ipsiPAS)) that required timing- and regional-specific information transfer across hemispheres for the induction of timing-dependent plasticity within M1 (see chapter 3). In the second study, we tested the influence of individual brain structure, as measured with voxel-based cortical thickness, on a standard PAS protocol (see chapter 4). In summary, we observed that the near-synchronous associativity taking place within M1 is not the only determinant influencing the outcome of PAS protocols. Rather, the online interaction of the cortical networks integrating information during a PAS intervention determines the outcome of the pairing of inputs in M1.
- Freie Schlagwörter (DE)
- Gepaarte assoziative stimulation, Gehirnstimulation, Transkranielle Magnetstimulation, Plastizität, Somatosensorischer Kortex, Motor Kortex, Interhemisphärische Inhibition, strukturelle Magnetresonanztomographie, kortikale Struktur
- Freie Schlagwörter (EN)
- Paired associative stimulation, Non-invasive brain stimulation, Transcranial Magnetic Stimulation, Plasticity, Timing-dependent plasticity, somatosensory cortex, motor cortex, interhemispheric inhibition, structural magnetic resonance imaging, cortical thickness
- Klassifikation (DDC)
- 610
- GutachterIn
- Prof. Dr. med. Joseph Claßen
- Prof. Dr. med. Michael Nitsche
- BetreuerIn
- Prof. Dr. Arno Villringer
- PhD Patrick Ragert
- Verlag
- Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-129770
- Veröffentlichungsdatum Qucosa
- 04.12.2013
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Englisch