- AutorIn
- Marco Lothar Krasselt
- Titel
- CD56+ Monocytes Have a Dysregulated Cytokine Response to LPS and Accumulate in Rheumatoid Arthritis and Immunosenescence
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-156166
- Datum der Einreichung
- 06.02.2014
- Datum der Verteidigung
- 16.10.2014
- Abstract (EN)
- Monocytes are no longer regarded as a homogenous cell population but can be divided, both phenotypically and functionally, into different subsets. In rheumatoid arthritis, the subpopulation of CD14bright/CD16+ monocytes is expanded and prone towards generation of Th17 cells. CD56+ monocytes represent a different subpopulation, which is also expanded in conditions associated with autoimmunity like inflammatory bowel diseases. The aim of the study was the quantification and functional characterization of the CD56+ monocyte subset in rheumatoid arthritis (RA). The work at hand shows that the frequency of CD56+ monocytes is also expanded in RA; moreover, this subpopulation seems to increase with age in healthy controls. This age association is completely lost in patients suffering from RA. Further functional investigations could demonstrate a dysregulated cytokine response to lipopolysaccharide (LPS) with an increased production of pro-inflammatory cytokines like TNFα as well as an increased spontaneous reactive oxygen intermediate (ROI) production. A longitudinal treatment study using Etanercept as an established TNFα-blocking agent revealed a decrease of the frequency of that cell population under therapy. This decrease was more pronounced in patients with a good treatment response as judged by the reduction of the disease activity score (DAS) 28. Summing up those results, the CD56+ monocyte subset might be involved in immunosenescence as well as in the pathogenesis of RA.
- Freie Schlagwörter (DE)
- TNF, DAS28, Rheumatoide Arthritis, Monozyten, CD56
- Freie Schlagwörter (EN)
- TNF, DAS28, Rheumatoid Arthritis, Monocytes, CD56
- Klassifikation (DDC)
- 610
- GutachterIn
- Prof. Dr. Frank Emmrich
- Prof. Dr. Ulrich Sack
- BetreuerIn
- Prof. Dr. Ulf Wagner
- Den akademischen Grad verleihende / prüfende Institution
- Universität Leipzig, Leipzig
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-156166
- Veröffentlichungsdatum Qucosa
- 24.11.2014
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Deutsch
- Englisch