- AutorIn
- Alexandra Wald
- Lea Deterding
- Melanie Maier
- Uwe G. Liebert
- Thomas Berg
- Hubert Wirtz
- Johannes Wiegand
- Titel
- Hepatitis B vaccination in end-stage pulmonary disease patients evaluated for lung transplantation
- Untertitel
- a retrospective single-center evaluation
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-205791
- Quellenangabe
- Ann Transplant, 2016; 21: 368-372 doi: 10.12659/AOT.897624
- Erstveröffentlichung
- 2016
- Abstract (EN)
- Background: In times of limited organs for transplantation, anti-HBc positive organs can be accepted for lung transplantation to increase the number of donors. Transplant recipients should be vaccinated against hepatitis B to prevent HBV infection. However, response after HBV vaccination has only been poorly evaluated in patients with end-stage pulmonary disease. Material/Methods: Anti-HBs titers of 40 anti-HBc negative patients with end-stage pulmonary disease evaluated for lung transplantation were analyzed with the Architect® system (Abbott, Germany). Responders, partial responders, or non-responders after HBV vaccination were defined by anti-HBs titers >100 IU/L, 10–100 IU/L, and <10 IU/L, respectively. Results: There were 34/40 individuals (85%) vaccinated against hepatitis B, and 6 were not vaccinated. Response, partial response, and non-response after vaccination were observed in 10/34 (29.4%), 11/34 (32.4%), and 13/34 (38.2%) of patients, respectively. Response to vaccination did not correlate with sex, pulmonary disease, comorbidities, immunosuppressive therapy, or smoking status. Conclusions: Although 85% of patients evaluated for lung transplantation were vaccinated against hepatitis B, 38.2% did not show an anti-HBs titer >10 IU/L. Thus, anti-HBs titers should be regularly monitored. Nonresponders should be considered for booster vaccinations, alternative vaccination schedules, or prophylactic treatment with a nucleos(t)ide analogue in case of transplantation of an anti-HBc–positive organ.
- Andere Ausgabe
- Link zur Originalpublikation in der Zeitschrift Annals of transplantation
Link: http://dx.doi.org/10.12659/AOT.897624 - Freie Schlagwörter (DE)
- Krankheitsübertragung, Infektionskrankheit, Herztransplantation, Lungentransplantation, Hepatitis B, Imfpung, Lamivudin
- Freie Schlagwörter (EN)
- disease transmission, infectious, heart-lung transplantation, hepatitis B vaccines, lamivudine
- Klassifikation (DDC)
- 610
- Herausgeber (Institution)
- Universität Leipzig
- Verlag
- International Scientific Information, Smithtown
- Förder- / Projektangaben
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-205791
- Veröffentlichungsdatum Qucosa
- 24.06.2016
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch