- AutorIn
- Gerd Birkenmeier
- Nasr Y. A. Hemdan
- Susanne Kurz
- Marina Bigl
- Philipp Pieroh
- Tewodros Debebe
- Martin Buchold
- Rene Thieme
- Gunnar Wichmann
- Faramarz Dehghani
- Titel
- Ethyl pyruvate combats human leukemia cells but spares normal blood cells
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-213853
- Quellenangabe
- PLoS ONE 11(8): e0161571 doi:10.1371/journal.pone.0161571
- Erstveröffentlichung
- 2016
- Abstract (EN)
- Ethyl pyruvate, a known ROS scavenger and anti-inflammatory drug was found to combat leukemia cells. Tumor cell killing was achieved by concerted action of necrosis/apoptosis induction, ATP depletion, and inhibition of glycolytic and para-glycolytic enzymes. Ethyl lactate was less harmful to leukemia cells but was found to arrest cell cycle in the G0/G1 phase. Both, ethyl pyruvate and ethyl lactate were identified as new inhibitors of GSK-3β. Despite the strong effect of ethyl pyruvate on leukemia cells, human cognate blood cells were only marginally affected. The data were compiled by immune blotting, flow cytometry, enzyme activity assay and gene array analysis. Our results inform new mechanisms of ethyl pyruvate-induced cell death, offering thereby a new treatment regime with a high therapeutic window for leukemic tumors.
- Andere Ausgabe
- Link zur Originalpublikation in der Zeitschrift Plos ONE
Link: http://dx.doi.org/10.1371/journal.pone.0161571 - Freie Schlagwörter (DE)
- Pyruvate, Krebs, Leukämie, Therapie
- Freie Schlagwörter (EN)
- ethyl pyruvate, cancer, leukemia, treatment
- Klassifikation (DDC)
- 601
- Herausgeber (Institution)
- Universität Leipzig
- Verlag
- Public Library of Science, San Francisco, Calif.
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-213853
- Veröffentlichungsdatum Qucosa
- 22.11.2016
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch