- AutorIn
- Jana Hertel
- Peter F. Stadler
- Titel
- Hairpins in a Haystack
- Untertitel
- recognizing microRNA precursors in comparative genomics data
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-321106
- Quellenangabe
- Bioinformatics Erscheinungsort: Oxford
Verlag: Oxford Univ. Press
Erscheinungsjahr: 2006
Jahrgang: 22
Heft: 14
Seiten: e197-e202
ISSN: 1460-2059 - Erstveröffentlichung
- 2006
- Abstract (EN)
- Recently, genome-wide surveys for non-coding RNAs have provided evidence for tens of thousands of previously undescribed evolutionary conserved RNAs with distinctive secondary structures. The annotation of these putative ncRNAs, however, remains a difficult problem. Here we describe an SVM-based approach that, in conjunction with a non-stringent filter for consensus secondary structures, is capable of efficiently recognizing microRNA precursors in multiple sequence alignments. The software was applied to recent genome-wide RNAz surveys of mammals, urochordates, and nematodes.
- Freie Schlagwörter (EN)
- bioinformatics, microRNA
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-321106
- Veröffentlichungsdatum Qucosa
- 06.11.2018
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch