- AutorIn
- Bogumił Kaczkowski
- Elfar Torarinsson
- Kristin Reiche
- Jakob Hull Havgaard
- Peter F. Stadler
- Jan Gorodkin
- Titel
- Structural profiles of human miRNA families from pairwise clustering
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-321144
- Quellenangabe
- Bioinformatics Erscheinungsort: Oxford
Verlag: Oxford Univ. Press
Erscheinungsjahr: 2009
Jahrgang: 25
Heft: 3
Seiten: 291-294
ISSN: 1460-2059 - Erstveröffentlichung
- 2009
- Abstract (EN)
- MicroRNAs (miRNAs) are a group of small, ∼21 nt long, riboreg-ulators inhibiting gene expression at a post-transcriptional level. Their most distinctive structural feature is the foldback hairpin of their precursor pre-miRNAs. Even though each pre-miRNA deposited in miRBase has its secondary structure already predicted, little is known about the patterns of structural conservation among pre-miRNAs. We address this issue by clustering the human pre-miRNA sequences based on pairwise, sequence and secondary structure alignment using FOLDALIGN, followed by global multiple alignment of obtained clusters by WAR. As a result, the common secondary structure was successfully determined for four FOLDALIGN clusters: the RF00027 structural family of the Rfam database and three clusters with previously undescribed consensus structures.
- Freie Schlagwörter (EN)
- bioinformatics, microRNA
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-321144
- Veröffentlichungsdatum Qucosa
- 06.11.2018
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch