- AutorIn
- Burkhard Morgenstern
- Nadine Werner
- Sonja J. Prohaska
- Rasmus Steinkamp
- Isabelle Schneider
- Amarendran R. Subramanian
- Peter F. Stadler
- Jan Weyer-Menkhoff
- Titel
- Multiple sequence alignment with user-defined constraints at GOBICS
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-321174
- Quellenangabe
- Bioinformatics Erscheinungsort: Oxford
Verlag: Oxford Univ. Press
Erscheinungsjahr: 2005
Jahrgang: 21
Heft: 7
Seiten: 1271-1273
ISSN: 1460-2059 - Erstveröffentlichung
- 2005
- Abstract (EN)
- Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to influence the alignment procedure. The user can specify parts of the sequences that are biologically related to each other; our software program uses these sites as anchor points and creates a multiple alignment respecting these user-defined constraints. By using known functionally, structurally or evolutionarily related positions of the input sequences as anchor points, our method can produce alignments that reflect the true biological relationships among the input sequences more accurately than fully automated procedures can do.
- Freie Schlagwörter (EN)
- bioinformatics, GOBICS
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-321174
- Veröffentlichungsdatum Qucosa
- 07.11.2018
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch