The role of the budding yeast RNA-binding proteins Khd1p and Loc1p in mRNA targeting

DSpace Repositorium (Manakin basiert)

The role of the budding yeast RNA-binding proteins Khd1p and Loc1p in mRNA targeting

Thas Moorthy, Balaji
Dateien:
Thumbnail
3.14 MB
PDF
Beschreibung: Ph.D dissertation
Zitierfähiger Link (URI): http://hdl.handle.net/10900/56594
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-565946
Dokumentart: Dissertation
Erscheinungsdatum: 2014-10-02
Sprache: Englisch
Fakultät: 7 Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich: Biochemie
Gutachter: Jansen, Ralf-Peter (Prof. Dr.)
Tag der mündl. Prüfung: 2014-09-26
DDC-Klassifikation: 570 - Biowissenschaften, Biologie
Schlagworte: Messenger RNA
Lizenz: http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en
Gedruckte Kopie bestellen: Print-on-Demand
Zur Langanzeige

Abstract:

mRNA localization is the common mechanism used by the cells to attain polarity and cellular asymmetry. In this work, I was focused on two RNA-binding proteins that involve in ASH1 mRNA localization in budding yeast. Khd1p associates with more than 1000 mRNA targets. Majority of them code for cell wall and secretory proteins. My results suggest that it has the potential to associate with endoplasmic reticulum (ER) and it is required for targeting of MID2 mRNA to ER. Loc1p is involved in the formation of nuclear ASH1-mRNP complex. During nuclear export, it is displaced by the She2p-She3p complex.

Das Dokument erscheint in: