CCR7 : Roles in cancer cell dissemination, migration and metastasis formation
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2014
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The International Journal of Biochemistry & Cell Biology. 2014, 54, pp. 78-82. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2014.07.002
Zusammenfassung
The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.
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Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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Chemokine receptor, Cancer, Metastasis formation, Cell migration, Lymph node homing
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LEGLER, Daniel F., Edith UETZ-VON ALLMEN, Mark A. HAUSER, 2014. CCR7 : Roles in cancer cell dissemination, migration and metastasis formation. In: The International Journal of Biochemistry & Cell Biology. 2014, 54, pp. 78-82. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2014.07.002BibTex
@article{Legler2014Roles-29330, year={2014}, doi={10.1016/j.biocel.2014.07.002}, title={CCR7 : Roles in cancer cell dissemination, migration and metastasis formation}, volume={54}, issn={1357-2725}, journal={The International Journal of Biochemistry & Cell Biology}, pages={78--82}, author={Legler, Daniel F. and Uetz-von Allmen, Edith and Hauser, Mark A.} }
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