Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men

Wirtz, Petra H.; Ehlert, Ulrike; Emini, Luljeta; Suter, Tobias

Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men

Dateien

Wirtz_0-276866.pdfGröße: 356.52 KBDownloads: 524

Datum

2008

Autor:innen

Wirtz, Petra H.

Ehlert, Ulrike

Emini, Luljeta

Suter, Tobias

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Psychoneuroendocrinology. 2008, 33(8), pp. 1102-1110. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2008.05.002

Zusammenfassung

Background: Body mass index (BMI) and mental stress seem to exert part of their cardiovascular risk by eliciting inflammation. However, the adverse effects of stress on inflammatory activity with BMI are not fully understood. We investigated whether higher BMI is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following stress in men while controlling for age and blood pressure. We measured glucorticoid inhibition of lipopolysaccharide (LPS)-stimulated release of the proinflammatory cytokine tumor necrosis factor (TNF)-a. Methods: Forty-two men (age range 21—65 years; BMI range 21—34 kg/m2) underwent the Trier Social Stress Test (combination of mock job interview and mental arithmetic task). Whole blood samples were taken immediately before and after stress, and during recovery up to 60 min poststress. Glucocorticoid sensitivity of LPS-stimulated TNF-a expression was assessed in vitro with and without coincubating increasing doses of dexamethasone. Moreover, salivary cortisol wasmeasured during the experiment and on a normal day for assessment of baseline circadian cortisol. Results: Higher BMI was associated with lower glucocorticoid sensitivity of monocyte TNF-a production after stress (main effect of BMI: p < 0.001) and with more pronounced decreases of glucocorticoid sensitivity following stress (interaction of stress-by-BMI: p = 0.002). Neither LPSstimulated TNF-a release nor baseline glucocorticoid sensitivity were associated with BMI. Similarly, BMI was not associated with salivary cortisol, either in reaction to stress or in circadian cortisol secretion. Conclusions: Our data suggest that with increasing BMI, glucocorticoids are less able to inhibit TNF-a production following stress. This might suggest a new mechanism linking BMI with elevated risk for adverse cardiovascular outcomes following stress.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

BMI; Atherosclerosis; Stress; Glucocorticoid sensitivity; TNF-α

Zitieren

ISO 690

WIRTZ, Petra H., Ulrike EHLERT, Luljeta EMINI, Tobias SUTER, 2008. Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men. In: Psychoneuroendocrinology. 2008, 33(8), pp. 1102-1110. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2008.05.002

BibTex

@article{Wirtz2008Highe-30752,
  year={2008},
  doi={10.1016/j.psyneuen.2008.05.002},
  title={Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men},
  number={8},
  volume={33},
  issn={0306-4530},
  journal={Psychoneuroendocrinology},
  pages={1102--1110},
  author={Wirtz, Petra H. and Ehlert, Ulrike and Emini, Luljeta and Suter, Tobias}
}

RDF

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risk by eliciting inflammation. However, the adverse effects of stress on inflammatory activity&#xD;
with BMI are not fully understood. We investigated whether higher BMI is associated with reduced&#xD;
glucocorticoid inhibition of inflammatory cytokine production following stress in men while&#xD;
controlling for age and blood pressure. We measured glucorticoid inhibition of lipopolysaccharide&#xD;
(LPS)-stimulated release of the proinflammatory cytokine tumor necrosis factor (TNF)-a.&#xD;
Methods: Forty-two men (age range 21—65 years; BMI range 21—34 kg/m2) underwent the Trier&#xD;
Social Stress Test (combination of mock job interview and mental arithmetic task). Whole blood&#xD;
samples were taken immediately before and after stress, and during recovery up to 60 min poststress.&#xD;
Glucocorticoid sensitivity of LPS-stimulated TNF-a expression was assessed in vitro with and&#xD;
without coincubating increasing doses of dexamethasone. Moreover, salivary cortisol wasmeasured&#xD;
during the experiment and on a normal day for assessment of baseline circadian cortisol.&#xD;
Results: Higher BMI was associated with lower glucocorticoid sensitivity of monocyte TNF-a&#xD;
production after stress (main effect of BMI: p &lt; 0.001) and with more pronounced decreases of&#xD;
glucocorticoid sensitivity following stress (interaction of stress-by-BMI: p = 0.002). Neither LPSstimulated&#xD;
TNF-a release nor baseline glucocorticoid sensitivity were associated with BMI.&#xD;
Similarly, BMI was not associated with salivary cortisol, either in reaction to stress or in circadian&#xD;
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