@article{Huetteroth2015Sweet-30445,
  year={2015},
  doi={10.1016/j.cub.2015.01.036},
  title={Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila},
  number={6},
  volume={25},
  issn={0960-9822},
  journal={Current Biology},
  pages={751--758},
  author={Huetteroth, Wolf and Perisse, Emmanuel and Lin, Suewei and Klappenbach, Martín and Burke, Christopher and Waddell, Scott}
}

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    <dcterms:abstract xml:lang="eng">Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β'2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.</dcterms:abstract>
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    <dcterms:title>Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila</dcterms:title>
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    <dc:contributor>Waddell, Scott</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:contributor>Lin, Suewei</dc:contributor>
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    <dc:creator>Huetteroth, Wolf</dc:creator>
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    <dc:language>eng</dc:language>
    <dc:creator>Lin, Suewei</dc:creator>
    <dc:creator>Waddell, Scott</dc:creator>
    <dc:creator>Klappenbach, Martín</dc:creator>
    <dc:creator>Perisse, Emmanuel</dc:creator>
    <dc:contributor>Perisse, Emmanuel</dc:contributor>
    <dc:contributor>Huetteroth, Wolf</dc:contributor>
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    <dc:contributor>Burke, Christopher</dc:contributor>
    <dcterms:issued>2015</dcterms:issued>
    <dc:creator>Burke, Christopher</dc:creator>
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    <dc:contributor>Klappenbach, Martín</dc:contributor>
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