@article{Morgenstern2015Dival-30955,
  year={2015},
  doi={10.1002/chem.201405733},
  title={Divalent Transition-Metal-Ion Stress Induces Prodigiosin Biosynthesis in Streptomyces coelicolor M145 : Formation of Coeligiosins},
  number={16},
  volume={21},
  issn={0947-6539},
  journal={Chemistry - A European Journal},
  pages={6027--6032},
  author={Morgenstern, Anne and Paetz, Christian and Behrend, Anne and Spiteller, Dieter}
}

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    <dc:creator>Paetz, Christian</dc:creator>
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    <dcterms:title>Divalent Transition-Metal-Ion Stress Induces Prodigiosin Biosynthesis in Streptomyces coelicolor M145 : Formation of Coeligiosins</dcterms:title>
    <dcterms:abstract xml:lang="eng">The bacterium Streptomyces coelicolor M145 reacts to transition-metal-ion stress with myriad growth responses, leading to different phenotypes. In particular, in the presence of Co&lt;sup&gt;2+&lt;/sup&gt; ions (0.7 mM) S. coelicolor consistently produced a red phenotype. This phenotype, when compared to the wild type, differed strongly in its production of volatile compounds as well as high molecular weight secondary metabolites. LC-MS analysis revealed that in the red phenotype the production of the prodigiosins, undecylprodigiosin and streptorubin B, was strongly induced and, in addition, several intense signals appeared in the LC-MS chromatogram. Using LC-MS/MS and NMR spectroscopy, two new prodigiosin derivatives were identified, that is, coeligiosin A and B, which contained an additional undecylpyrrolyl side chain attached to the central carbon of the tripyrrole ring system of undecylprodigiosin or streptorubin B. This example demonstrates that environmental factors such as heavy metal ion stress can not only induce the production of otherwise not observed metabolites from so called sleeping genes but alter the products from well-studied biosynthetic pathways.</dcterms:abstract>
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    <dc:contributor>Paetz, Christian</dc:contributor>
    <dc:contributor>Behrend, Anne</dc:contributor>
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