@article{Merkle2015-12-23aptam-32337,
  year={2015},
  doi={10.1039/C5OB02026C},
  title={The dual aptamer approach : rational design of a high-affinity FAD aptamer},
  number={2},
  volume={14},
  issn={1477-0520},
  journal={Organic and Biomolecular Chemistry},
  pages={447--450},
  author={Merkle, Tobias and Holder, Isabelle T. and Hartig, Jörg S.}
}

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    <dcterms:abstract xml:lang="eng">A design strategy for high-affinity aptamers of complex biomolecules is presented. We developed an RNA with FAD-binding properties by combining known ATP- and FMN-aptamers. Cooperative binding of FAD was shown by SPR spectroscopy and fluorescence assays. The strategy should be transferable to several other biomolecules.</dcterms:abstract>
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