@article{Triphan2016scree-35029,
  year={2016},
  doi={10.1038/srep27000},
  title={A screen for constituents of motor control and decision making in Drosophila reveals visual distance-estimation neurons},
  volume={6},
  journal={Scientific Reports},
  author={Triphan, Tilman and Nern, Aljoscha and Roberts, Sonia F. and Korff, Wyatt and Naiman, Daniel Q. and Strauss, Roland},
  note={Article Number: 27000}
}

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    <dc:rights>Attribution 4.0 International</dc:rights>
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    <dcterms:abstract xml:lang="eng">Climbing over chasms larger than step size is vital to fruit flies, since foraging and mating are achieved while walking. Flies avoid futile climbing attempts by processing parallax-motion vision to estimate gap width. To identify neuronal substrates of climbing control, we screened a large collection of fly lines with temporarily inactivated neuronal populations in a novel high-throughput assay described here. The observed climbing phenotypes were classified; lines in each group are reported. Selected lines were further analysed by high-resolution video cinematography. One striking class of flies attempts to climb chasms of unsurmountable width; expression analysis guided us to C2 optic-lobe interneurons. Inactivation of C2 or the closely related C3 neurons with highly specific intersectional driver lines consistently reproduced hyperactive climbing whereas strong or weak artificial depolarization of C2/C3 neurons strongly or mildly decreased climbing frequency. Contrast-manipulation experiments support our conclusion that C2/C3 neurons are part of the distance-evaluation system.</dcterms:abstract>
    <dc:creator>Roberts, Sonia F.</dc:creator>
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    <dc:contributor>Roberts, Sonia F.</dc:contributor>
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    <dcterms:title>A screen for constituents of motor control and decision making in Drosophila reveals visual distance-estimation neurons</dcterms:title>
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