Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

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2016
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Perisse, Emmanuel
Owald, David
Barnstedt, Oliver
Talbot, Clifford B.
Waddell, Scott
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Neuron. 2016, 90(5), pp. 1086-1099. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2016.04.034
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In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, MVP2 neuron output is only essential for expression of short-term aversive memory. Stimulating MVP2 neurons preferentially inhibits the odor-evoked activity of avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances odor avoidance. In contrast, odor-evoked activity of MVP2 neurons is elevated in hungry flies, and their feed-forward inhibition is required for expression of appetitive memory at all times. Moreover, imposing MVP2 activity promotes inappropriate appetitive memory expression in food-satiated flies. Aversive learning and appetitive motivation therefore toggle alternate modes of a common feed-forward inhibitory MVP2 pathway to promote conditioned odor avoidance or approach.

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ISO 690PERISSE, Emmanuel, David OWALD, Oliver BARNSTEDT, Clifford B. TALBOT, Wolf HUETTEROTH, Scott WADDELL, 2016. Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body. In: Neuron. 2016, 90(5), pp. 1086-1099. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2016.04.034
BibTex
@article{Perisse2016-06-01Avers-34791,
  year={2016},
  doi={10.1016/j.neuron.2016.04.034},
  title={Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body},
  number={5},
  volume={90},
  issn={0896-6273},
  journal={Neuron},
  pages={1086--1099},
  author={Perisse, Emmanuel and Owald, David and Barnstedt, Oliver and Talbot, Clifford B. and Huetteroth, Wolf and Waddell, Scott}
}
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