Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement

Lade...
Vorschaubild
Dateien
Bibby_0-350023.pdf
Bibby_0-350023.pdfGröße: 696.85 KBDownloads: 237
Datum
2013
Autor:innen
Bibby, Jaclyn
Keegan, Ronan M.
Winn, Martyn D.
Rigden, Daniel J.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Hybrid
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Acta Crystallographica Section D : Biological Crystallography. 2013, 69(11), pp. 2194-2201. ISSN 0907-4449. eISSN 1399-0047. Available under: doi: 10.1107/S0907444913018453
Zusammenfassung

AMPLE is a program developed for clustering and truncating ab initio protein structure predictions into search models for molecular replacement. Here, it is shown that its core cluster-and-truncate methods also work well for processing NMR ensembles into search models. Rosetta remodelling helps to extend success to NMR structures bearing low sequence identity or high structural divergence from the target protein. Potential future routes to improved performance are considered and practical, general guidelines on using AMPLE are provided.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690BIBBY, Jaclyn, Ronan M. KEEGAN, Olga MAYANS, Martyn D. WINN, Daniel J. RIGDEN, 2013. Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement. In: Acta Crystallographica Section D : Biological Crystallography. 2013, 69(11), pp. 2194-2201. ISSN 0907-4449. eISSN 1399-0047. Available under: doi: 10.1107/S0907444913018453
BibTex
@article{Bibby2013-11-01Appli-34986,
  year={2013},
  doi={10.1107/S0907444913018453},
  title={Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement},
  number={11},
  volume={69},
  issn={0907-4449},
  journal={Acta Crystallographica Section D : Biological Crystallography},
  pages={2194--2201},
  author={Bibby, Jaclyn and Keegan, Ronan M. and Mayans, Olga and Winn, Martyn D. and Rigden, Daniel J.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/34986">
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Bibby, Jaclyn</dc:contributor>
    <dc:contributor>Winn, Martyn D.</dc:contributor>
    <dcterms:title>Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement</dcterms:title>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Bibby, Jaclyn</dc:creator>
    <dc:creator>Mayans, Olga</dc:creator>
    <dc:contributor>Rigden, Daniel J.</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/34986"/>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/34986/3/Bibby_0-350023.pdf"/>
    <dc:contributor>Keegan, Ronan M.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Winn, Martyn D.</dc:creator>
    <dc:contributor>Mayans, Olga</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/34986/3/Bibby_0-350023.pdf"/>
    <dcterms:abstract xml:lang="eng">AMPLE is a program developed for clustering and truncating ab initio protein structure predictions into search models for molecular replacement. Here, it is shown that its core cluster-and-truncate methods also work well for processing NMR ensembles into search models. Rosetta remodelling helps to extend success to NMR structures bearing low sequence identity or high structural divergence from the target protein. Potential future routes to improved performance are considered and practical, general guidelines on using AMPLE are provided.</dcterms:abstract>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-08-09T13:01:50Z</dcterms:available>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Keegan, Ronan M.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-08-09T13:01:50Z</dc:date>
    <dcterms:issued>2013-11-01</dcterms:issued>
    <dc:creator>Rigden, Daniel J.</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen