@article{Cohen2015-10-06damag-35182,
  year={2015},
  doi={10.1038/srep14756},
  title={IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity},
  volume={5},
  journal={Scientific Reports},
  author={Cohen, Idan and Rider, Peleg and Voronov, Elena and Tomas, Martin and Tudor, Cicerone and Wegner, Mareike and Brondani, Lydia and Ferrando-May, Elisa and Apte, Ron N. and Schneider, Robert},
  note={Article Number: 14756}
}

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    <dcterms:issued>2015-10-06</dcterms:issued>
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    <dcterms:abstract xml:lang="eng">Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, IL-1α could directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity. Here we demonstrate localization of the cytokine to DNA-damage sites and its subsequent secretion. Interestingly, its nucleo-cytosolic shuttling after DNA damage sensing is regulated by histone deacetylases (HDAC) and IL-1α acetylation. To demonstrate the physiological significance of this newly discovered mechanism, we used IL-1α knockout mice and show that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade in vivo that contributes to efficient tissue repair and wound healing.</dcterms:abstract>
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    <dc:contributor>Tudor, Cicerone</dc:contributor>
    <dc:creator>Cohen, Idan</dc:creator>
    <dc:contributor>Wegner, Mareike</dc:contributor>
    <dc:creator>Schneider, Robert</dc:creator>
    <dc:contributor>Voronov, Elena</dc:contributor>
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    <dc:creator>Ferrando-May, Elisa</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:creator>Rider, Peleg</dc:creator>
    <dc:creator>Brondani, Lydia</dc:creator>
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    <dc:contributor>Rider, Peleg</dc:contributor>
    <dc:creator>Tudor, Cicerone</dc:creator>
    <dc:contributor>Ferrando-May, Elisa</dc:contributor>
    <dcterms:title>IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity</dcterms:title>
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    <dc:contributor>Apte, Ron N.</dc:contributor>
    <dc:creator>Tomas, Martin</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-08T13:15:09Z</dc:date>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-08T13:15:09Z</dcterms:available>
    <dc:language>eng</dc:language>
    <dc:creator>Apte, Ron N.</dc:creator>
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    <dc:creator>Wegner, Mareike</dc:creator>
    <dc:contributor>Brondani, Lydia</dc:contributor>
    <dc:contributor>Schneider, Robert</dc:contributor>
    <dc:contributor>Tomas, Martin</dc:contributor>
    <dc:creator>Voronov, Elena</dc:creator>
    <dc:contributor>Cohen, Idan</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
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