A unified framework for estimating parameters of kinetic biological models

Baker, Syed Murtuza; Poskar, C. Hart; Schreiber, Falk; Junker, Björn H.

A unified framework for estimating parameters of kinetic biological models

Dateien

Baker_0-395174.pdfGröße: 1.44 MBDownloads: 339

Datum

2015

Autor:innen

Baker, Syed Murtuza

Poskar, C. Hart

Schreiber, Falk

Junker, Björn H.

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Informatik und Informationswissenschaft

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

BMC Bioinformatics. 2015, 16, 104. eISSN 1471-2105. Available under: doi: 10.1186/s12859-015-0500-9

Zusammenfassung

Utilizing kinetic models of biological systems commonly require computational approaches to estimate parameters, posing a variety of challenges due to their highly non-linear and dynamic nature, which is further complicated by the issue of non-identifiability. We propose a novel parameter estimation framework by combining approaches for solving identifiability with a recently introduced filtering technique that can uniquely estimate parameters where conventional methods fail. This framework first conducts a thorough analysis to identify and classify the non-identifiable parameters and provides a guideline for solving them. If no feasible solution can be found, the framework instead initializes the filtering technique with informed prior to yield a unique solution.

Fachgebiet (DDC)

004 Informatik

Zitieren

ISO 690

BAKER, Syed Murtuza, C. Hart POSKAR, Falk SCHREIBER, Björn H. JUNKER, 2015. A unified framework for estimating parameters of kinetic biological models. In: BMC Bioinformatics. 2015, 16, 104. eISSN 1471-2105. Available under: doi: 10.1186/s12859-015-0500-9

BibTex

@article{Baker2015-12unifi-37681,
  year={2015},
  doi={10.1186/s12859-015-0500-9},
  title={A unified framework for estimating parameters of kinetic biological models},
  volume={16},
  journal={BMC Bioinformatics},
  author={Baker, Syed Murtuza and Poskar, C. Hart and Schreiber, Falk and Junker, Björn H.},
  note={Article Number: 104}
}

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Universitätsbibliographie

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