Guiding the interactive exploration of metabolic pathway interconnections
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Approaches to investigate biological processes have been of strong interest in the past few years and are the focus of several research areas, especially Systems Biology. Biochemical networks as representations of processes are very important for a comprehensive understanding of living beings. Drawings of these networks are often visually overloaded and do not scale. A common solution to deal with this complexity is to divide the complete network, for example, the metabolism, into a large set of single pathways that are hierarchically structured. If those pathways are visualized, this strategy generates additional navigation and exploration problems as the user loses the context within the complete network. In this article, we present a general solution to this problem of visualizing interconnected pathways and discuss it in context of biochemical networks. Our new visualization approach supports the analyst in obtaining an overview to related pathways if they are working within a particular pathway of interest. By using glyphs, brushing, and topological information of the related pathways, our interactive visualization is able to intuitively guide the exploration and navigation process, and thus the analysis processes too. To deal with real data and current networks, our tool has been implemented as a plugin for the VANTED system.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
JUSUFI, Ilir, Christian KLUKAS, Andreas KERREN, Falk SCHREIBER, 2012. Guiding the interactive exploration of metabolic pathway interconnections. In: Information Visualization. 2012, 11(2), pp. 136-150. ISSN 1473-8716. eISSN 1473-8724. Available under: doi: 10.1177/1473871611405677BibTex
@article{Jusufi2012-04Guidi-37706,
year={2012},
doi={10.1177/1473871611405677},
title={Guiding the interactive exploration of metabolic pathway interconnections},
number={2},
volume={11},
issn={1473-8716},
journal={Information Visualization},
pages={136--150},
author={Jusufi, Ilir and Klukas, Christian and Kerren, Andreas and Schreiber, Falk}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/37706">
<dcterms:title>Guiding the interactive exploration of metabolic pathway interconnections</dcterms:title>
<dcterms:issued>2012-04</dcterms:issued>
<dc:language>eng</dc:language>
<dc:creator>Klukas, Christian</dc:creator>
<dc:creator>Kerren, Andreas</dc:creator>
<dc:contributor>Kerren, Andreas</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:abstract xml:lang="eng">Approaches to investigate biological processes have been of strong interest in the past few years and are the focus of several research areas, especially Systems Biology. Biochemical networks as representations of processes are very important for a comprehensive understanding of living beings. Drawings of these networks are often visually overloaded and do not scale. A common solution to deal with this complexity is to divide the complete network, for example, the metabolism, into a large set of single pathways that are hierarchically structured. If those pathways are visualized, this strategy generates additional navigation and exploration problems as the user loses the context within the complete network. In this article, we present a general solution to this problem of visualizing interconnected pathways and discuss it in context of biochemical networks. Our new visualization approach supports the analyst in obtaining an overview to related pathways if they are working within a particular pathway of interest. By using glyphs, brushing, and topological information of the related pathways, our interactive visualization is able to intuitively guide the exploration and navigation process, and thus the analysis processes too. To deal with real data and current networks, our tool has been implemented as a plugin for the VANTED system.</dcterms:abstract>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37706/1/Jusufi_0-396423.pdf"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-24T13:12:12Z</dc:date>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
<dc:rights>terms-of-use</dc:rights>
<dc:contributor>Schreiber, Falk</dc:contributor>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37706"/>
<dc:creator>Schreiber, Falk</dc:creator>
<dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37706/1/Jusufi_0-396423.pdf"/>
<dc:contributor>Jusufi, Ilir</dc:contributor>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-24T13:12:12Z</dcterms:available>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
<dc:creator>Jusufi, Ilir</dc:creator>
<dc:contributor>Klukas, Christian</dc:contributor>
</rdf:Description>
</rdf:RDF>
