Integrative Analysis of Metabolic Models : from Structure to Dynamics

Hartmann, Anja; Schreiber, Falk

Integrative Analysis of Metabolic Models : from Structure to Dynamics

Dateien

Hartmann_0-396984.pdfGröße: 2.36 MBDownloads: 217

Datum

2015

Autor:innen

Hartmann, Anja

Schreiber, Falk

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Informatik und Informationswissenschaft

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Frontiers in Bioengineering and Biotechnology. 2015, 2, 91. eISSN 2296-4185. Available under: doi: 10.3389/fbioe.2014.00091

Zusammenfassung

The characterization of biological systems with respect to their behavior and functionality based on versatile biochemical interactions is a major challenge. To understand these complex mechanisms at systems level modeling approaches are investigated. Different modeling formalisms allow metabolic models to be analyzed depending on the question to be solved, the biochemical knowledge and the availability of experimental data. Here, we describe a method for an integrative analysis of the structure and dynamics represented by qualitative and quantitative metabolic models. Using various formalisms, the metabolic model is analyzed from different perspectives. Determined structural and dynamic properties are visualized in the context of the metabolic model. Interaction techniques allow the exploration and visual analysis thereby leading to a broader understanding of the behavior and functionality of the underlying biological system. The System Biology Metabolic Model Framework (SBM (2) - Framework) implements the developed method and, as an example, is applied for the integrative analysis of the crop plant potato.

Fachgebiet (DDC)

004 Informatik

Zitieren

ISO 690

HARTMANN, Anja, Falk SCHREIBER, 2015. Integrative Analysis of Metabolic Models : from Structure to Dynamics. In: Frontiers in Bioengineering and Biotechnology. 2015, 2, 91. eISSN 2296-4185. Available under: doi: 10.3389/fbioe.2014.00091

BibTex

@article{Hartmann2015-01-26Integ-38024,
  year={2015},
  doi={10.3389/fbioe.2014.00091},
  title={Integrative Analysis of Metabolic Models : from Structure to Dynamics},
  volume={2},
  journal={Frontiers in Bioengineering and Biotechnology},
  author={Hartmann, Anja and Schreiber, Falk},
  note={Article Number: 91}
}

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Universitätsbibliographie

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