@article{Hernaus2015-04-14evide-38497,
  year={2015},
  doi={10.1038/tp.2015.37},
  title={No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder},
  volume={5},
  journal={Translational Psychiatry},
  author={Hernaus, Dennis and Collip, Dina and Kasanova, Zuzana and Winz, Oliver and Heinzel, Alexander and van Amelsvoort, Therese and Shali, Siamak Mohammadkhani and Booij, Jan and Pruessner, Jens C. and Myin-Germeys, Inez},
  note={Article Number: e547}
}

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    <dc:contributor>Winz, Oliver</dc:contributor>
    <dc:creator>Heinzel, Alexander</dc:creator>
    <dc:contributor>Shali, Siamak Mohammadkhani</dc:contributor>
    <dc:creator>Winz, Oliver</dc:creator>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
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    <dc:language>eng</dc:language>
    <dc:creator>van Amelsvoort, Therese</dc:creator>
    <dc:creator>Hernaus, Dennis</dc:creator>
    <dc:creator>Kasanova, Zuzana</dc:creator>
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    <dc:contributor>Booij, Jan</dc:contributor>
    <dc:creator>Booij, Jan</dc:creator>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:abstract xml:lang="eng">Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.</dcterms:abstract>
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    <dc:contributor>Kasanova, Zuzana</dc:contributor>
    <dc:contributor>Hernaus, Dennis</dc:contributor>
    <dc:creator>Myin-Germeys, Inez</dc:creator>
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    <dc:contributor>Myin-Germeys, Inez</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:43:18Z</dc:date>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38497"/>
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    <dc:contributor>van Amelsvoort, Therese</dc:contributor>
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    <dc:contributor>Collip, Dina</dc:contributor>
    <dc:creator>Shali, Siamak Mohammadkhani</dc:creator>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <dc:creator>Collip, Dina</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:43:18Z</dcterms:available>
    <dcterms:issued>2015-04-14</dcterms:issued>
    <dc:contributor>Heinzel, Alexander</dc:contributor>
    <dcterms:title>No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder</dcterms:title>
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