Neuropathology of stress

Lucassen, Paul J.; Pruessner, Jens C.; Sousa, Nuno; Almeida, Osborne F. X.; Van Dam, Anne Marie; Rajkowska, Grazyna; Swaab, Dick F.; Czéh, Boldizsár

Neuropathology of stress

Dateien

Lucassen_0-401762.pdfGröße: 2.11 MBDownloads: 376

Datum

2014

Autor:innen

Lucassen, Paul J.

Pruessner, Jens C.

Sousa, Nuno

Almeida, Osborne F. X.

Van Dam, Anne Marie

Rajkowska, Grazyna

Swaab, Dick F.

Czéh, Boldizsár

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Acta Neuropathologica. 2014, 127(1), pp. 109-135. ISSN 0001-6322. eISSN 1432-0533. Available under: doi: 10.1007/s00401-013-1223-5

Zusammenfassung

Environmental challenges are part of daily life for any individual. In fact, stress appears to be increasingly present in our modern, and demanding, industrialized society. Virtually every aspect of our body and brain can be influenced by stress and although its effects are partly mediated by powerful corticosteroid hormones that target the nervous system, relatively little is known about when, and how, the effects of stress shift from being beneficial and protective to becoming deleterious. Decades of stress research have provided valuable insights into whether stress can directly induce dysfunction and/or pathological alterations, which elements of stress exposure are responsible, and which structural substrates are involved. Using a broad definition of pathology, we here review the "neuropathology of stress" and focus on structural consequences of stress exposure for different regions of the rodent, primate and human brain. We discuss cytoarchitectural, neuropathological and structural plasticity measures as well as more recent neuroimaging techniques that allow direct monitoring of the spatiotemporal effects of stress and the role of different CNS structures in the regulation of the hypothalamic-pituitary-adrenal axis in human brain. We focus on the hypothalamus, hippocampus, amygdala, nucleus accumbens, prefrontal and orbitofrontal cortex, key brain regions that not only modulate emotions and cognition but also the response to stress itself, and discuss disorders like depression, post-traumatic stress disorder, Cushing syndrome and dementia.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

HPA axis; Hippocampus; Prefrontal cortex; Amygdala; Mood disorder; PTSD

Zitieren

ISO 690

LUCASSEN, Paul J., Jens C. PRUESSNER, Nuno SOUSA, Osborne F. X. ALMEIDA, Anne Marie VAN DAM, Grazyna RAJKOWSKA, Dick F. SWAAB, Boldizsár CZÉH, 2014. Neuropathology of stress. In: Acta Neuropathologica. 2014, 127(1), pp. 109-135. ISSN 0001-6322. eISSN 1432-0533. Available under: doi: 10.1007/s00401-013-1223-5

BibTex

@article{Lucassen2014-01Neuro-38460,
  year={2014},
  doi={10.1007/s00401-013-1223-5},
  title={Neuropathology of stress},
  number={1},
  volume={127},
  issn={0001-6322},
  journal={Acta Neuropathologica},
  pages={109--135},
  author={Lucassen, Paul J. and Pruessner, Jens C. and Sousa, Nuno and Almeida, Osborne F. X. and Van Dam, Anne Marie and Rajkowska, Grazyna and Swaab, Dick F. and Czéh, Boldizsár}
}

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