Ligand-dependent ribozymes

Felletti, Michele; Hartig, Jörg S.

Ligand-dependent ribozymes

Dateien

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Datum

2017

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Wiley Interdisciplinary Reviews (WIREs) : RNA. 2017, 8(2), e1395. ISSN 1757-7004. eISSN 1757-7012. Available under: doi: 10.1002/wrna.1395

Zusammenfassung

The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon of RNA-based functions in natural systems. Similarly to the activity of protein enzymes that are often modulated by the presence of an interaction partner, some examples of naturally occurring ribozymes are influenced by ligands that can either act as cofactors or allosteric modulators. Recent discoveries of new and widespread ribozyme motifs in many different genetic contexts point toward the existence of further ligand-dependent RNA catalysts. In addition to the presence of ligand-dependent ribozymes in nature, researchers have engineered ligand dependency into natural and artificial ribozymes. Because RNA functions can often be assembled in a truly modular way, many different systems have been obtained utilizing different ligand-sensing domains and ribozyme activities in diverse applications. We summarize the occurrence of ligand-dependent ribozymes in nature and the many examples realized by researchers that engineered ligand-dependent catalytic RNA motifs. We will also highlight methods for obtaining ligand dependency as well as discuss the many interesting applications of ligand-controlled catalytic RNAs.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

FELLETTI, Michele, Jörg S. HARTIG, 2017. Ligand-dependent ribozymes. In: Wiley Interdisciplinary Reviews (WIREs) : RNA. 2017, 8(2), e1395. ISSN 1757-7004. eISSN 1757-7012. Available under: doi: 10.1002/wrna.1395

BibTex

@article{Felletti2017-03Ligan-38789,
  year={2017},
  doi={10.1002/wrna.1395},
  title={Ligand-dependent ribozymes},
  number={2},
  volume={8},
  issn={1757-7004},
  journal={Wiley Interdisciplinary Reviews (WIREs) : RNA},
  author={Felletti, Michele and Hartig, Jörg S.},
  note={Article Number: e1395}
}

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