Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

Oppelt, Claus; Wutzler, Rebecca; Holst, Dietrich von

Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

Dateien

Oppelt.pdfGröße: 767.47 KBDownloads: 435

Datum

2010

Autor:innen

Oppelt, Claus

Wutzler, Rebecca

Holst, Dietrich von

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Immunogenetics. 2010, 62(9), pp. 613-622. ISSN 0093-7711. eISSN 1432-1211. Available under: doi: 10.1007/s00251-010-0466-8

Zusammenfassung

Genes of the major histocompatibility complex (MHC) mainly code for proteins of the immune system of jawed vertebrates. In particular, MHC class I and II cell surface proteins are crucial for the self/non-self discrimination of the adaptive immune system and are the most polymorphic genes in vertebrates. Positive selection, gene duplications and pseudogenes shape the face of the MHC and reflect a highly dynamic evolution. Here, we present for the first time data of the highly polymorphic MHC class II DRB exon 2 of a representative of the mammalian order scandentia, the northern tree shrew Tupaia belangeri. We found up to eight different alleles per individual and determined haplotype constitution by intensively studying their inheritance. The alleles were assigned to four putative loci, all of which were polymorphic. Only the most polymorphic locus was subject to positive selection within the antigen binding sites and only alleles of this locus were transcribed.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Major histocompatibility complex, Peptide binding region, Polymorphism, Balancing selection, Positive selection, Tupaia

Zitieren

ISO 690

OPPELT, Claus, Rebecca WUTZLER, Dietrich von HOLST, 2010. Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri). In: Immunogenetics. 2010, 62(9), pp. 613-622. ISSN 0093-7711. eISSN 1432-1211. Available under: doi: 10.1007/s00251-010-0466-8

BibTex

@article{Oppelt2010Chara-13572,
  year={2010},
  doi={10.1007/s00251-010-0466-8},
  title={Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)},
  number={9},
  volume={62},
  issn={0093-7711},
  journal={Immunogenetics},
  pages={613--622},
  author={Oppelt, Claus and Wutzler, Rebecca and Holst, Dietrich von},
  note={Electronic supplementary material The online version of this article (doi:10.1007/s00251-010-0466-8) contains supplementary material, which is available to authorized users.}
}

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Kommentar zur Publikation

Electronic supplementary material The online version of this article (doi:10.1007/s00251-010-0466-8) contains supplementary material, which is available to authorized users.

Universitätsbibliographie

Ja