Receptor-mediated tumor targeting based on peptide hormones

Mező, Gábor; Manea, Marilena

Receptor-mediated tumor targeting based on peptide hormones

Dateien

Manea_EODD_2010.pdfGröße: 1.23 MBDownloads: 1678

Datum

2010

Autor:innen

Mező, Gábor

Manea, Marilena

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Expert opinion on drug delivery. 2010, 7(1), pp. 79-96. ISSN 1742-5247. eISSN 1744-7593. Available under: doi: 10.1517/17425240903418410

Zusammenfassung

Importance of the field: Tumor targeting with peptides is based on the discovery that receptors for many regulatory peptides are overexpressed in tumor cells, compared with their expression in normal tissues. Consequently, these peptides and their analogues can be used as carriers/targeting moieties for the preparation of diagnostic and therapeutic agents that have increased selectivity and decreased peripheral toxicity.
Areas covered in this review: Here an overview is given of the most relevant gonadotropin-releasing hormone (GnRH) and somatostatin derivatives, as well as of their applications in cancer diagnosis and therapy. For this purpose, recently published data in these areas (mostly articles published from 2000 to 2009) were reviewed.
What the reader will gain: In contrast to other regulatory peptides that stimulate the tumor growth, GnRH and somatostatin derivatives have inhibitory effect; therefore, they were used primarily for the preparation of various conjugates to be used in targeted chemotherapy, targeted radiotherapy, photodynamic therapy, boron neutron capture therapy and cancer diagnosis. Some of these conjugates have already found clinical applications, whereas others are now in preclinical and clinical trials.
Take home message: Tumor targeting with hormone peptides provides a basis for the development of new diagnostic and therapeutic approaches for cancer.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

cancer diagnosis and therapy, drug delivery systems, gonadotropin-releasing hormone, receptor-mediated tumor targeting, somatostatin

Zitieren

ISO 690

MEZŐ, Gábor, Marilena MANEA, 2010. Receptor-mediated tumor targeting based on peptide hormones. In: Expert opinion on drug delivery. 2010, 7(1), pp. 79-96. ISSN 1742-5247. eISSN 1744-7593. Available under: doi: 10.1517/17425240903418410

BibTex

@article{Mezo2010Recep-13592,
  year={2010},
  doi={10.1517/17425240903418410},
  title={Receptor-mediated tumor targeting based on peptide hormones},
  number={1},
  volume={7},
  issn={1742-5247},
  journal={Expert opinion on drug delivery},
  pages={79--96},
  author={Mező, Gábor and Manea, Marilena}
}

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Universitätsbibliographie

Ja