@article{Plock2007-10Activ-14273,
  year={2007},
  doi={10.1016/j.jhep.2007.04.016},
  title={Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver},
  number={4},
  volume={47},
  issn={0168-8278},
  journal={Journal of Hepatology},
  pages={538--545},
  author={Plock, Jan and Frese, Steffen and Keogh, Adrian and Bisch-Knaden, Sonja and Ayuni, Erick and Corazza, Nadia and Weikert, Christian and Jakob, Stephan and Erni, Dominique and Dufour, Jean-Francois and Brunner, Thomas and Candinas, Daniel and Stroka, Deborah}
}

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    <dc:creator>Weikert, Christian</dc:creator>
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    <dc:contributor>Jakob, Stephan</dc:contributor>
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    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:creator>Plock, Jan</dc:creator>
    <dc:creator>Frese, Steffen</dc:creator>
    <dc:creator>Keogh, Adrian</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-19T14:37:32Z</dc:date>
    <dc:contributor>Dufour, Jean-Francois</dc:contributor>
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    <dc:creator>Brunner, Thomas</dc:creator>
    <dcterms:abstract xml:lang="eng">Background/Aims:&lt;br /&gt;We investigated the molecular response of a non-ischemic hypoxic stress in the liver, in particular, to distinguish its hepatoprotective potential.&lt;br /&gt;Methods:&lt;br /&gt;The livers of mice were subjected to non-ischemic hypoxia by clamping the hepatic-artery (HA) for 2h while maintaining portal circulation. Hypoxia was defined by a decrease in oxygen saturation, the activation of hypoxia-inducible factor (HIF)-1 and the mRNA up-regulation of responsive genes. To demonstrate that the molecular response to hypoxia may in part be hepatoprotective, pre-conditioned animals were injected with an antibody against Fas (Jo2) to induce acute liver failure. Hepatocyte apoptosis was monitored by caspase-3 activity, cleavage of lamin A and animal survival.&lt;br /&gt;Results:&lt;br /&gt;Clamping the HA induced a hypoxic stress in the liver in the absence of severe metabolic distress or tissue damage. The hypoxic stimulus was sufficient to activate the HIF-1 signalling pathway and up-regulate hepatoprotective genes. Pre-conditioning the liver with hypoxia was able to delay the onset of Fas-mediated apoptosis and prolong animal survival.&lt;br /&gt;Conclusions:&lt;br /&gt;Our data reveal that hepatic cells can sense and respond to a decrease in tissue oxygenation, and furthermore, that activation of hypoxia-inducible signalling pathways function in part to promote liver cell survival.</dcterms:abstract>
    <dc:creator>Erni, Dominique</dc:creator>
    <dc:contributor>Keogh, Adrian</dc:contributor>
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    <dc:contributor>Candinas, Daniel</dc:contributor>
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    <dcterms:title>Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver</dcterms:title>
    <dc:creator>Bisch-Knaden, Sonja</dc:creator>
    <dc:contributor>Bisch-Knaden, Sonja</dc:contributor>
    <dc:contributor>Frese, Steffen</dc:contributor>
    <dc:contributor>Erni, Dominique</dc:contributor>
    <dc:creator>Candinas, Daniel</dc:creator>
    <dc:contributor>Plock, Jan</dc:contributor>
    <dc:contributor>Corazza, Nadia</dc:contributor>
    <dcterms:bibliographicCitation>Journal of Hepatology ; 47 (2007), 4. - pp. 538-545</dcterms:bibliographicCitation>
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    <dc:language>eng</dc:language>
    <dc:creator>Corazza, Nadia</dc:creator>
    <dc:creator>Dufour, Jean-Francois</dc:creator>
    <dc:contributor>Stroka, Deborah</dc:contributor>
    <dc:creator>Jakob, Stephan</dc:creator>
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    <dc:contributor>Ayuni, Erick</dc:contributor>
    <dc:creator>Stroka, Deborah</dc:creator>
    <dc:creator>Ayuni, Erick</dc:creator>
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