Inducible non-lymphoid expression of Fas ligand is responsible for superantigen-triggered peripheral deletion of T cells

Bonfoco, Emanuela; Stuart, Patrick M.; Brunner, Thomas; Lin, Tesu; Griffith, Thomas S.; Gao, Yakun; Nakajima, Hiroo; Henkart, Pierre A.; Ferguson, Thomas A.; Green, Douglas R.

Inducible non-lymphoid expression of Fas ligand is responsible for superantigen-triggered peripheral deletion of T cells

Dateien

1998_Bonfoco_Inducible.pdfGröße: 348.92 KBDownloads: 227

Datum

1998

Autor:innen

Bonfoco, Emanuela

Stuart, Patrick M.

Brunner, Thomas

Lin, Tesu

Griffith, Thomas S.

Gao, Yakun

Nakajima, Hiroo

Henkart, Pierre A.

Ferguson, Thomas A.

Green, Douglas R.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Immunity. 1998, 9(5), pp. 711-720. ISSN 1074-7613. Available under: doi: 10.1016/S1074-7613(00)80668-8

Zusammenfassung

Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)–induced peripheral deletion of Vβ8+ T cells. We found that peripheral deletion was defective in radiation chimeras with nonfunctional tissue FasL, regardless of the FasL status of the bone marrow–derived cells. SEB induced a dramatic upregulation of FasL expression and function in nonlymphoid cells of liver and small intestine. This effect was resistant to inhibition by cyclosporin A, which also failed to inhibit peripheral deletion. In SCID animals nonlymphoid tissues did not express FasL in response to SEB unless transplanted lymphocytes were present. Thus, some immune responses induce FasL in nonlymphoid tissues, which in turn kills activated lymphocytes, leading to peripheral T cell deletion.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

BONFOCO, Emanuela, Patrick M. STUART, Thomas BRUNNER, Tesu LIN, Thomas S. GRIFFITH, Yakun GAO, Hiroo NAKAJIMA, Pierre A. HENKART, Thomas A. FERGUSON, Douglas R. GREEN, 1998. Inducible non-lymphoid expression of Fas ligand is responsible for superantigen-triggered peripheral deletion of T cells. In: Immunity. 1998, 9(5), pp. 711-720. ISSN 1074-7613. Available under: doi: 10.1016/S1074-7613(00)80668-8

BibTex

@article{Bonfoco1998Induc-14310,
  year={1998},
  doi={10.1016/S1074-7613(00)80668-8},
  title={Inducible non-lymphoid expression of Fas ligand is responsible for superantigen-triggered peripheral deletion of T cells},
  number={5},
  volume={9},
  issn={1074-7613},
  journal={Immunity},
  pages={711--720},
  author={Bonfoco, Emanuela and Stuart, Patrick M. and Brunner, Thomas and Lin, Tesu and Griffith, Thomas S. and Gao, Yakun and Nakajima, Hiroo and Henkart, Pierre A. and Ferguson, Thomas A. and Green, Douglas R.}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14310">
    <dc:creator>Ferguson, Thomas A.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-05T07:21:37Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:bibliographicCitation>First publ. in: Immunity ; 9 (1998), 5. - pp. 711-720</dcterms:bibliographicCitation>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Nakajima, Hiroo</dc:contributor>
    <dc:creator>Griffith, Thomas S.</dc:creator>
    <dcterms:issued>1998</dcterms:issued>
    <dc:creator>Bonfoco, Emanuela</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14310/2/1998_Bonfoco_Inducible.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-05T07:21:37Z</dc:date>
    <dc:creator>Stuart, Patrick M.</dc:creator>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dcterms:abstract xml:lang="eng">Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)–induced peripheral deletion of Vβ8+ T cells. We found that peripheral deletion was defective in radiation chimeras with nonfunctional tissue FasL, regardless of the FasL status of the bone marrow–derived cells. SEB induced a dramatic upregulation of FasL expression and function in nonlymphoid cells of liver and small intestine. This effect was resistant to inhibition by cyclosporin A, which also failed to inhibit peripheral deletion. In SCID animals nonlymphoid tissues did not express FasL in response to SEB unless transplanted lymphocytes were present. Thus, some immune responses induce FasL in nonlymphoid tissues, which in turn kills activated lymphocytes, leading to peripheral T cell deletion.</dcterms:abstract>
    <dc:creator>Henkart, Pierre A.</dc:creator>
    <dc:creator>Green, Douglas R.</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Nakajima, Hiroo</dc:creator>
    <dc:contributor>Stuart, Patrick M.</dc:contributor>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:contributor>Ferguson, Thomas A.</dc:contributor>
    <dc:contributor>Green, Douglas R.</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14310/2/1998_Bonfoco_Inducible.pdf"/>
    <dc:creator>Gao, Yakun</dc:creator>
    <dc:contributor>Gao, Yakun</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Bonfoco, Emanuela</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14310"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Lin, Tesu</dc:contributor>
    <dc:contributor>Henkart, Pierre A.</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Lin, Tesu</dc:creator>
    <dc:contributor>Griffith, Thomas S.</dc:contributor>
    <dcterms:title>Inducible non-lymphoid expression of Fas ligand is responsible for superantigen-triggered peripheral deletion of T cells</dcterms:title>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Nein