Allatostatin modulates skeletal muscle performance in crustaceans through pre- and postsynaptic effects

Kreißl, Sabine; Weiss, Torsten; Djokaj, Stefan; Balezina, Olga; Rathmayer, Werner

Allatostatin modulates skeletal muscle performance in crustaceans through pre- and postsynaptic effects

Dateien

eujoofneurokreissl.pdfGröße: 633.08 KBDownloads: 538

Datum

1999

Autor:innen

Kreißl, Sabine

Weiss, Torsten

Djokaj, Stefan

Balezina, Olga

Rathmayer, Werner

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

European Journal of Neuroscience. 1999, 11(7), pp. 2519-2530. ISSN 0953-816X. Available under: doi: 10.1046/j.1460-9568.1999.00674.x

Zusammenfassung

Allatostatins, originally identified in insects as peptide inhibitors of juvenile hormone biosynthesis, are regarded as potent inhibitory regulators of intestinal muscles in insects and crustaceans. However, accumulating data indicate that allatostatins might also be involved in modulation of skeletal neuromuscular events. We show that most ganglia of two isopod crustaceans (Idotea baltica and I. emarginata) contain pairs of large, allatostatin-immunoreactive motor neurons which supply several segmental muscles. Among them are the dorsal extensor muscles, of which some fibres receive immunoreactive, varicose innervation. We demonstrate, on identified muscle fibres, that allatostatin exerts a twofold inhibitory effect: it reduces contractions of single voltage-clamped fibres, and it decreases the amplitude of evoked excitatory junctional currents recorded from individual release boutons. No change in excitation-contraction threshold or in passive membrane parameters was observed. As the amplitude of miniature currents generated by spontaneously released single transmitter quanta was not changed, the inhibitory effect of the peptide on junctional currents must be of presynaptic origin. Supportive results were obtained on leg muscles of the crab Eriphia spinifrons, where allatostatin decreased evoked synaptic currents by reducing the mean number of transmitter quanta released by presynaptic depolarization without affecting the amplitudes of currents generated by single quanta. This effect of allatostatin was similar for two functionally different neurons, the slow and the fast closer excitor.
The data show that allatostatin occurs in identified motor neurons of Idotea and exerts complementary pre- and postsynaptic modulatory effects which reduce muscle responses. Thus, allatostatin counteracts the effects of another neuropeptide, proctolin, which is also present in Idotea and causes potentiating effects on the same muscle fibres.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Eriphia spinifrons, Idotea, inhibition, modulation, muscle contraction, neuromuscular transmission, neuropeptide

Zitieren

ISO 690

KREISSL, Sabine, Torsten WEISS, Stefan DJOKAJ, Olga BALEZINA, Werner RATHMAYER, 1999. Allatostatin modulates skeletal muscle performance in crustaceans through pre- and postsynaptic effects. In: European Journal of Neuroscience. 1999, 11(7), pp. 2519-2530. ISSN 0953-816X. Available under: doi: 10.1046/j.1460-9568.1999.00674.x

BibTex

@article{Kreil1999Allat-16259,
  year={1999},
  doi={10.1046/j.1460-9568.1999.00674.x},
  title={Allatostatin modulates skeletal muscle performance in crustaceans through pre- and postsynaptic effects},
  number={7},
  volume={11},
  issn={0953-816X},
  journal={European Journal of Neuroscience},
  pages={2519--2530},
  author={Kreißl, Sabine and Weiss, Torsten and Djokaj, Stefan and Balezina, Olga and Rathmayer, Werner}
}

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Universitätsbibliographie

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