The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

Santner, Tobias; Siegmund, Vanessa; Marx, Andreas; Micura, Ronald

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

Dateien

Marx_synthesis.pdfGröße: 1.77 MBDownloads: 265

Datum

2012

Autor:innen

Santner, Tobias

Siegmund, Vanessa

Marx, Andreas

Micura, Ronald

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Bioorganic & Medicinal Chemistry. 2012, 20(7), pp. 2416-2418. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2012.01.044

Zusammenfassung

Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 20-SeCH3-uridine and 20-SeCH3-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding
nucleoside triphosphates and distinct mutants of T7 RNA polymerase. In the present note, we introduce the chemical synthesis of the novel 20-methylseleno-20-deoxyadenosine and -guanosine 50-triphosphates (20-SeCH3-ATP and 20-SeCH3-GTP) that represent further candidates for the enzymatic RNA synthesis with engineered RNA polymerases.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

SANTNER, Tobias, Vanessa SIEGMUND, Andreas MARX, Ronald MICURA, 2012. The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates. In: Bioorganic & Medicinal Chemistry. 2012, 20(7), pp. 2416-2418. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2012.01.044

BibTex

@article{Santner2012-04-01synth-18857,
  year={2012},
  doi={10.1016/j.bmc.2012.01.044},
  title={The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates},
  number={7},
  volume={20},
  issn={0968-0896},
  journal={Bioorganic & Medicinal Chemistry},
  pages={2416--2418},
  author={Santner, Tobias and Siegmund, Vanessa and Marx, Andreas and Micura, Ronald}
}

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