Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights

Grädler, Ulrich; Fuchß, Thomas; Ulrich, Wolf-Rüdiger; Boer, Rainer; Strub, Andreas; Hesslinger, Christian; Anézo, Céline; Diederichs, Kay; Zaliani, Andrea

Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights

Dateien

Diedrichs_Novel.pdfGröße: 2.84 MBDownloads: 1927

Datum

2011

Autor:innen

Grädler, Ulrich

Fuchß, Thomas

Ulrich, Wolf-Rüdiger

Boer, Rainer

Strub, Andreas

Hesslinger, Christian

Anézo, Céline

Diederichs, Kay

Zaliani, Andrea

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Bioorganic & Medicinal Chemistry Letters. 2011, 21(14), pp. 4228-4232. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2011.05.073

Zusammenfassung

Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Nitric oxide synthase, inflammation, crystal structure, structure-based design, selectivity, inhibitor

Zitieren

ISO 690

GRÄDLER, Ulrich, Thomas FUCHSS, Wolf-Rüdiger ULRICH, Rainer BOER, Andreas STRUB, Christian HESSLINGER, Céline ANÉZO, Kay DIEDERICHS, Andrea ZALIANI, 2011. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights. In: Bioorganic & Medicinal Chemistry Letters. 2011, 21(14), pp. 4228-4232. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2011.05.073

BibTex

@article{Gradler2011-07-15Novel-19253,
  year={2011},
  doi={10.1016/j.bmcl.2011.05.073},
  title={Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights},
  number={14},
  volume={21},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={4228--4232},
  author={Grädler, Ulrich and Fuchß, Thomas and Ulrich, Wolf-Rüdiger and Boer, Rainer and Strub, Andreas and Hesslinger, Christian and Anézo, Céline and Diederichs, Kay and Zaliani, Andrea}
}

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Universitätsbibliographie

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