PrPs: Proteins with a purpose ; Lessons from the zebrafish

Málaga-Trillo, Edward; Sempou, Aimilia

PrPs: Proteins with a purpose ; Lessons from the zebrafish

Dateien

Malaga_PrPs.pdfGröße: 2.81 MBDownloads: 148

Datum

2009

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Prion. 2009, 3(3), pp. 129-133. ISSN 1933-6896. Available under: doi: 10.4161/pri.3.3.9651

Zusammenfassung

The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform. Much less understood is how this misfolded isoform causes deadly brain illnesses. Neurodegeneration in prion disease is often seen as a consequence of abnormal PrP function yet, amazingly little is known about the normal, physiological role of PrP. In particular, the absence of obvious phenotypes in PrP knockout mice has prevented scientists from answering this important question. Using knockdown approaches, we previously produced clear PrP loss-of-function phenotypes in zebrafish embryos. Analysis of these phenotypes revealed that PrP can modulate E-cadherin-based cell-cell adhesion, thereby controlling essential morphogenetic cell movements in the early gastrula. Our data also showed that PrP itself can elicit homophilic cell-cell adhesion and trigger intracellular signaling via Src-related kinases. Importantly, these molecular functions of PrP are conserved from fish to mammals. Here we discuss the use of the zebrafish in prion biology and how it may advance our understanding of the roles of PrP in health and disease.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

MÁLAGA-TRILLO, Edward, Aimilia SEMPOU, 2009. PrPs: Proteins with a purpose ; Lessons from the zebrafish. In: Prion. 2009, 3(3), pp. 129-133. ISSN 1933-6896. Available under: doi: 10.4161/pri.3.3.9651

BibTex

@article{MalagaTrillo2009Prote-19333,
  year={2009},
  doi={10.4161/pri.3.3.9651},
  title={PrPs: Proteins with a purpose ; Lessons from the zebrafish},
  number={3},
  volume={3},
  issn={1933-6896},
  journal={Prion},
  pages={129--133},
  author={Málaga-Trillo, Edward and Sempou, Aimilia}
}

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