@article{Boll2004-02Impro-40637,
  year={2004},
  doi={10.1046/j.1471-4159.2003.02198.x},
  title={Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347},
  number={3},
  volume={88},
  issn={0022-3042},
  journal={Journal of Neurochemistry},
  pages={698--707},
  author={Boll, Jette Bisgaard and Geist, Marie Aavang and Kaminski Schierle, Gabriele S. and Petersen, Karina and Leist, Marcel and Vaudano, Elisabetta}
}

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    <dc:creator>Kaminski Schierle, Gabriele S.</dc:creator>
    <dc:creator>Boll, Jette Bisgaard</dc:creator>
    <dc:creator>Vaudano, Elisabetta</dc:creator>
    <dc:contributor>Petersen, Karina</dc:contributor>
    <dcterms:abstract xml:lang="eng">Transplantation of embryonic nigral tissue ameliorates functional deficiencies in Parkinson's disease (PD). A main constraint of neural grafting is the poor survival of dopaminergic neurones grafted into patients. Studies in rats indicated that many grafted neurones die by apoptosis. CEP-1347 is a mixed-lineage-kinase (MLK) inhibitor with neuroprotective action in several in vitro and in vivo models of neuronal apoptosis. We studied the effect of CEP-1347 on the survival of embryonic rat dopaminergic neurones in culture, and after transplantation in hemiparkinsonian rats. CEP-1347 and the alternative MLK inhibitor CEP-11004 significantly increased the survival of dopaminergic neurones in primary cultures from rat ventral mesencephalon and in Mn2+-exposed PC12 cells, a surrogate model of dopaminergic lethal stress. Moreover, combined treatment of the grafting cell suspension and the host animal with CEP-1347 significantly improved the long-term survival of rat dopaminergic neurones transplanted into the striatum of hemiparkinsonian rats. Also, the protective effect of CEP-1347 resulted in an increase in total graft size and in enhanced fibre outgrowth. Thus, treatment with CEP-1347 improved dopaminergic cell survival under severe stress and might be useful to improve the positive outcome of transplantation therapy in PD and reduce the amount of human tissue required.</dcterms:abstract>
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    <dcterms:issued>2004-02</dcterms:issued>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:creator>Geist, Marie Aavang</dc:creator>
    <dc:contributor>Geist, Marie Aavang</dc:contributor>
    <dc:contributor>Boll, Jette Bisgaard</dc:contributor>
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    <dc:contributor>Vaudano, Elisabetta</dc:contributor>
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    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:creator>Petersen, Karina</dc:creator>
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    <dc:contributor>Kaminski Schierle, Gabriele S.</dc:contributor>
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