Meta-All : a system for managing metabolic pathway information

Lade...
Vorschaubild
Dateien
Weise_-2--wrl18rolr9yw1.pdf
Weise_-2--wrl18rolr9yw1.pdfGröße: 1.43 MBDownloads: 372
Datum
2006
Autor:innen
Weise, Stephan
Grosse, Ivo
Klukas, Christian
Koschützki, Dirk
Scholz, Uwe
Junker, Björn H.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
BMC Bioinformatics. 2006, 7(1), 465. ISSN 1471-2105. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-465
Zusammenfassung

Background

Many attempts are being made to understand biological subjects at a systems level. A major resource for these approaches are biological databases, storing manifold information about DNA, RNA and protein sequences including their functional and structural motifs, molecular markers, mRNA expression levels, metabolite concentrations, protein-protein interactions, phenotypic traits or taxonomic relationships. The use of these databases is often hampered by the fact that they are designed for special application areas and thus lack universality. Databases on metabolic pathways, which provide an increasingly important foundation for many analyses of biochemical processes at a systems level, are no exception from the rule. Data stored in central databases such as KEGG, BRENDA or SABIO-RK is often limited to read-only access. If experimentalists want to store their own data, possibly still under investigation, there are two possibilities. They can either develop their own information system for managing that own data, which is very time-consuming and costly, or they can try to store their data in existing systems, which is often restricted. Hence, an out-of-the-box information system for managing metabolic pathway data is needed.

Results

We have designed META-ALL, an information system that allows the management of metabolic pathways, including reaction kinetics, detailed locations, environmental factors and taxonomic information. Data can be stored together with quality tags and in different parallel versions. META-ALL uses Oracle DBMS and Oracle Application Express. We provide the META-ALL information system for download and use. In this paper, we describe the database structure and give information about the tools for submitting and accessing the data. As a first application of META-ALL, we show how the information contained in a detailed kinetic model can be stored and accessed.

Conclusion

META-ALL is a system for managing information about metabolic pathways. It facilitates the handling of pathway-related data and is designed to help biochemists and molecular biologists in their daily research. It is available on the Web at http://bic-gh.de/meta-all and can be downloaded free of charge and installed locally.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
004 Informatik
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690WEISE, Stephan, Ivo GROSSE, Christian KLUKAS, Dirk KOSCHÜTZKI, Uwe SCHOLZ, Falk SCHREIBER, Björn H. JUNKER, 2006. Meta-All : a system for managing metabolic pathway information. In: BMC Bioinformatics. 2006, 7(1), 465. ISSN 1471-2105. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-465
BibTex
@article{Weise2006MetaA-40688,
  year={2006},
  doi={10.1186/1471-2105-7-465},
  title={Meta-All : a system for managing metabolic pathway information},
  number={1},
  volume={7},
  issn={1471-2105},
  journal={BMC Bioinformatics},
  author={Weise, Stephan and Grosse, Ivo and Klukas, Christian and Koschützki, Dirk and Scholz, Uwe and Schreiber, Falk and Junker, Björn H.},
  note={Article Number: 465}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40688">
    <dc:contributor>Scholz, Uwe</dc:contributor>
    <dc:creator>Weise, Stephan</dc:creator>
    <dc:creator>Grosse, Ivo</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/2.0/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dc:rights>Attribution 2.0 Generic</dc:rights>
    <dc:creator>Schreiber, Falk</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40688/1/Weise_-2--wrl18rolr9yw1.pdf"/>
    <dc:creator>Junker, Björn H.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-22T08:46:16Z</dc:date>
    <dc:creator>Scholz, Uwe</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;&lt;br /&gt;Many attempts are being made to understand biological subjects at a systems level. A major resource for these approaches are biological databases, storing manifold information about DNA, RNA and protein sequences including their functional and structural motifs, molecular markers, mRNA expression levels, metabolite concentrations, protein-protein interactions, phenotypic traits or taxonomic relationships. The use of these databases is often hampered by the fact that they are designed for special application areas and thus lack universality. Databases on metabolic pathways, which provide an increasingly important foundation for many analyses of biochemical processes at a systems level, are no exception from the rule. Data stored in central databases such as KEGG, BRENDA or SABIO-RK is often limited to read-only access. If experimentalists want to store their own data, possibly still under investigation, there are two possibilities. They can either develop their own information system for managing that own data, which is very time-consuming and costly, or they can try to store their data in existing systems, which is often restricted. Hence, an out-of-the-box information system for managing metabolic pathway data is needed.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;We have designed META-ALL, an information system that allows the management of metabolic pathways, including reaction kinetics, detailed locations, environmental factors and taxonomic information. Data can be stored together with quality tags and in different parallel versions. META-ALL uses Oracle DBMS and Oracle Application Express. We provide the META-ALL information system for download and use. In this paper, we describe the database structure and give information about the tools for submitting and accessing the data. As a first application of META-ALL, we show how the information contained in a detailed kinetic model can be stored and accessed.&lt;br /&gt;&lt;br /&gt;Conclusion&lt;br /&gt;&lt;br /&gt;META-ALL is a system for managing information about metabolic pathways. It facilitates the handling of pathway-related data and is designed to help biochemists and molecular biologists in their daily research. It is available on the Web at http://bic-gh.de/meta-all and can be downloaded free of charge and installed locally.</dcterms:abstract>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40688"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40688/1/Weise_-2--wrl18rolr9yw1.pdf"/>
    <dc:contributor>Klukas, Christian</dc:contributor>
    <dc:contributor>Junker, Björn H.</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Koschützki, Dirk</dc:creator>
    <dc:creator>Klukas, Christian</dc:creator>
    <dc:contributor>Koschützki, Dirk</dc:contributor>
    <dc:contributor>Schreiber, Falk</dc:contributor>
    <dc:contributor>Weise, Stephan</dc:contributor>
    <dcterms:issued>2006</dcterms:issued>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-22T08:46:16Z</dcterms:available>
    <dc:contributor>Grosse, Ivo</dc:contributor>
    <dcterms:title>Meta-All : a system for managing metabolic pathway information</dcterms:title>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen