@article{Gideon2020-03-01Kinet-47577,
  year={2020},
  doi={10.1210/clinem/dgz190},
  title={Kinetics and interrelations of the renin aldosterone response to acute psychosocial stress : a neglected stress system},
  number={3},
  volume={105},
  issn={0021-972X},
  journal={The Journal of clinical endocrinology and metabolism},
  pages={e762--e773},
  author={Gideon, Angelina and Sauter, Christine and Fieres, Judy and Berger, Thilo and Renner, Britta and Wirtz, Petra H.}
}

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    <dc:contributor>Berger, Thilo</dc:contributor>
    <dc:creator>Gideon, Angelina</dc:creator>
    <dc:creator>Fieres, Judy</dc:creator>
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    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:creator>Sauter, Christine</dc:creator>
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    <dc:creator>Berger, Thilo</dc:creator>
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    <dcterms:title>Kinetics and interrelations of the renin aldosterone response to acute psychosocial stress : a neglected stress system</dcterms:title>
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    <dc:contributor>Gideon, Angelina</dc:contributor>
    <dc:creator>Renner, Britta</dc:creator>
    <dc:contributor>Renner, Britta</dc:contributor>
    <dc:contributor>Wirtz, Petra H.</dc:contributor>
    <dc:contributor>Sauter, Christine</dc:contributor>
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    <dc:creator>Wirtz, Petra H.</dc:creator>
    <dcterms:abstract xml:lang="eng">Context:&lt;br /&gt;The Renin-Angiotensin-Aldosterone-System (RAAS) plays an important role in cardiovascular homeostasis and its dysfunction relates to negative health consequences. Acute psychosocial stress seems to activate the RAAS in humans, but stress kinetics and interrelations of RAAS parameters as compared to a non-stress control group remain inconclusive.&lt;br /&gt;&lt;br /&gt;Objective:&lt;br /&gt;We systematically investigated in a randomized placebo-controlled design stress kinetics and interrelations of the reactivity of RAAS parameters measured in plasma and saliva to standardized acute psychosocial stress induction.&lt;br /&gt;&lt;br /&gt;Methods:&lt;br /&gt;58 healthy young men were assigned to either a stress or a placebo-control group. The stress group underwent the Trier-Social-Stress-Test (TSST), while the control group underwent the placebo-TSST. We repeatedly assessed plasma renin, plasma and salivary aldosterone, before, and up to 3h after stress/placebo. We simultaneously assessed salivary cortisol to validate successful stress induction and to test for interrelations.&lt;br /&gt;&lt;br /&gt;Results:&lt;br /&gt;Acute psychosocial stress induced significant increases in all endocrine measures as compared to placebo-stress (p´s≤.041). Highest renin levels were observed 1min after stress, highest aldosterone and cortisol levels 10 and 20min after stress, with salivary aldosterone starting earlier at 1min after stress. Renin completed recovery at 10min, cortisol at 60min, salivary aldosterone at 90min, and plasma aldosterone at 180min after stress. Stress increase scores of all endocrine measures related to each other, as did renin and cortisol AUCi´s and salivary and plasma aldosterone AUCi´s (p´s≤.047).&lt;br /&gt;&lt;br /&gt;Conclusions:&lt;br /&gt;Our findings suggest that in humans acute psychosocial stress induces a differential and interrelated RAAS parameter activation pattern. Potential implications for stress-related cardiovascular risk remain to be elucidated.</dcterms:abstract>
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