@article{Mix2021-10Micro-55697,
  year={2021},
  doi={10.1038/s41435-021-00149-1},
  title={Microscale communication between bacterial pathogens and the host epithelium},
  number={5-6},
  volume={22},
  issn={1466-4879},
  journal={Genes and Immunity},
  pages={247--254},
  author={Mix, Ann-Kathrin and Goob, Griseldis and Sontowski, Erik and Hauck, Christof R.}
}

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    <dc:creator>Sontowski, Erik</dc:creator>
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    <dcterms:abstract xml:lang="eng">Pathogenic bacteria have evolved a variety of highly selective adhesins allowing these microbes to engage specific surface determinants of their eukaryotic host cells. Receptor clustering induced by the multivalent microorganisms will not only anchor the bacteria to the tissue, but will inevitably trigger host cell signaling. It has become clear, that these bacteria-initiated signaling events can be seen as a form of localized communication with host epithelial cells. Such a microscale communication can have immediate consequences in the form of changes in host cell membrane morphology or cytoskeletal organization, but can also lead to transcriptional responses and medium- and long-term alterations in cellular physiology. In this review, we will discuss several examples of this form of microscale communication between bacterial pathogens and mammalian host cells and try to delineate their downstream ramifications in the infection process. Furthermore, we will highlight recent findings that specialized pathogenic bacteria utilize the adhesin-based interaction to diffuse the short-range messenger molecule nitric oxide into the host tissue. While anti-adhesive strategies to disrupt the initial bacterial attachment have not yet translated into medical applications, the ability to interfere with the microscale communication emanating on the host side provides an unconventional approach for preventing infectious diseases.</dcterms:abstract>
    <dc:creator>Hauck, Christof R.</dc:creator>
    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dc:contributor>Goob, Griseldis</dc:contributor>
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    <dc:contributor>Mix, Ann-Kathrin</dc:contributor>
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    <dc:contributor>Sontowski, Erik</dc:contributor>
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