Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

Barra, Lena; Awakawa, Takayoshi; Abe, Ikuro

Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

Dateien

Barra_2-19udo0hxacx6m2.pdfGröße: 7.44 MBDownloads: 142

Datum

2022

Autor:innen

Barra, Lena

Awakawa, Takayoshi

Abe, Ikuro

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

JACS Au. American Chemical Society (ACS). 2022, 2(9), pp. 1950-1963. ISSN 2691-3704. eISSN 2691-3704. Available under: doi: 10.1021/jacsau.2c00391

Zusammenfassung

Enzymes involved in secondary metabolite biosynthetic pathways have typically evolutionarily diverged from their counterparts functioning in primary metabolism. They often catalyze diverse and complex chemical transformations and are thus a treasure trove for the discovery of unique enzyme-mediated chemistries. Besides major natural product classes, such as terpenoids, polyketides, and ribosomally or nonribosomally synthesized peptides, biosynthetic investigations of noncanonical natural product biosynthetic pathways often reveal functionally distinct enzyme chemistries. In this Perspective, we aim to highlight challenges and opportunities of biosynthetic investigations on noncanonical natural product pathways that utilize primary metabolites as building blocks, otherwise generally considered as enzyme cofactors. A focus is made on the discovered chemical and enzymological novelties.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

enzyme cofactors, natural products, nicotinamide adenine dinucleotide, S-adenosylmethionine, flavin mononucleotide, heme, pyridoxal phosphate-dependent enzymes

Zitieren

ISO 690

BARRA, Lena, Takayoshi AWAKAWA, Ikuro ABE, 2022. Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis. In: JACS Au. American Chemical Society (ACS). 2022, 2(9), pp. 1950-1963. ISSN 2691-3704. eISSN 2691-3704. Available under: doi: 10.1021/jacsau.2c00391

BibTex

@article{Barra2022-09-26Nonca-58430,
  year={2022},
  doi={10.1021/jacsau.2c00391},
  title={Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis},
  number={9},
  volume={2},
  issn={2691-3704},
  journal={JACS Au},
  pages={1950--1963},
  author={Barra, Lena and Awakawa, Takayoshi and Abe, Ikuro}
}

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