@article{Michalek2022-09-05LRH1N-57992,
  year={2022},
  doi={10.15252/embr.202154195},
  title={LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance},
  number={9},
  volume={23},
  issn={1469-221X},
  journal={EMBO reports},
  author={Michalek, Svenja and Goj, Thomas and Plazzo, Anna Pia and Marovca, Blerim and Bornhauser, Beat and Brunner, Thomas}
}

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    <dc:creator>Plazzo, Anna Pia</dc:creator>
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    <dcterms:abstract xml:lang="eng">Nuclear receptors are transcription factors with important functions in a variety of physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity using glucocorticoids is a cornerstone in the treatment of patients with T cell acute lymphoblastic leukemia (T-ALL), and resistance to GC-induced cell death is associated with poor outcome and a high risk for relapse. Next to ligand-binding, heterodimerization with other transcription factors presents an important mechanism for the regulation of GR activity. Here, we describe a GC-induced direct association of the Liver Receptor Homolog-1 (LRH-1) with the GR in the nucleus, which results in reciprocal inhibition of transcriptional activity. Pharmacological and molecular interference with LRH-1 impairs proliferation and survival in T-ALL and causes a profound sensitization to GC-induced cell death, even in GC-resistant T-ALL. Our data illustrate that direct interaction between GR and LRH-1 critically regulates glucocorticoid sensitivity in T-ALL opening up new perspectives for developing innovative therapeutic approaches to treat GC-resistant T-ALL.</dcterms:abstract>
    <dc:creator>Bornhauser, Beat</dc:creator>
    <dc:contributor>Bornhauser, Beat</dc:contributor>
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    <dc:creator>Michalek, Svenja</dc:creator>
    <dc:creator>Marovca, Blerim</dc:creator>
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    <dc:creator>Goj, Thomas</dc:creator>
    <dcterms:issued>2022-09-05</dcterms:issued>
    <dc:contributor>Michalek, Svenja</dc:contributor>
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    <dcterms:title>LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance</dcterms:title>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dc:contributor>Marovca, Blerim</dc:contributor>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dc:contributor>Goj, Thomas</dc:contributor>
    <dc:contributor>Plazzo, Anna Pia</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-07-08T12:23:06Z</dc:date>
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    <dc:contributor>Brunner, Thomas</dc:contributor>
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