Counting on Death : Quantitative aspects of Bcl-2 family regulation
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
The Bcl-2 protein family members critically regulate mitochondrial outer membrane permeabilization (MOMP), a point-of-no-return in the intrinsic and extrinsic apoptosis pathways. The common view on qualitative interaction and activation patterns of the three subclasses, the BH3-only proteins, prosurvivals, and effectors, is static and currently being revolutionized by an emerging understanding of the complex dynamic equilibria that govern cellular fate. Recent experimental evidence on protein associations with the mitochondrial outer membrane, retrotranslocation to the cytosol, and differential binding affinities in aqueous and membranous environments instigate the development of a revised model of Bcl-2 family interplay. Likely, the dynamic processes and their respective timescales need to be taken into account to authentically understand and, by extension, to generate reliable predictions on cellular decision-making. Here, we review the quantitative aspects of Bcl-2 family-regulated MOMP. In particular, we discuss affinity binding constants of protein-protein associations and velocities of post-translational modifications, membrane (retro-) translocations, and effector oligomerization. Moreover, we provide insights into how these kinetic and network information enable systems biological approaches, further enhancing our understanding of the complex molecular mechanisms governing MOMP.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
HANTUSCH, Annika, Markus REHM, Thomas BRUNNER, 2018. Counting on Death : Quantitative aspects of Bcl-2 family regulation. In: The FEBS Journal. 2018, 285(22), pp. 4124-4138. ISSN 0014-2956. eISSN 1742-4658. Available under: doi: 10.1111/febs.14516BibTex
@article{Hantusch2018-11Count-42818, year={2018}, doi={10.1111/febs.14516}, title={Counting on Death : Quantitative aspects of Bcl-2 family regulation}, number={22}, volume={285}, issn={0014-2956}, journal={The FEBS Journal}, pages={4124--4138}, author={Hantusch, Annika and Rehm, Markus and Brunner, Thomas} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/42818"> <dcterms:abstract xml:lang="eng">The Bcl-2 protein family members critically regulate mitochondrial outer membrane permeabilization (MOMP), a point-of-no-return in the intrinsic and extrinsic apoptosis pathways. The common view on qualitative interaction and activation patterns of the three subclasses, the BH3-only proteins, prosurvivals, and effectors, is static and currently being revolutionized by an emerging understanding of the complex dynamic equilibria that govern cellular fate. Recent experimental evidence on protein associations with the mitochondrial outer membrane, retrotranslocation to the cytosol, and differential binding affinities in aqueous and membranous environments instigate the development of a revised model of Bcl-2 family interplay. Likely, the dynamic processes and their respective timescales need to be taken into account to authentically understand and, by extension, to generate reliable predictions on cellular decision-making. Here, we review the quantitative aspects of Bcl-2 family-regulated MOMP. In particular, we discuss affinity binding constants of protein-protein associations and velocities of post-translational modifications, membrane (retro-) translocations, and effector oligomerization. Moreover, we provide insights into how these kinetic and network information enable systems biological approaches, further enhancing our understanding of the complex molecular mechanisms governing MOMP.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-09T12:08:54Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-09T12:08:54Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Hantusch, Annika</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42818"/> <dc:creator>Hantusch, Annika</dc:creator> <dc:language>eng</dc:language> <dc:creator>Rehm, Markus</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42818/1/Hantusch_2-1avtn44ywrh1m6.pdf"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:rights>terms-of-use</dc:rights> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:contributor>Brunner, Thomas</dc:contributor> <dcterms:issued>2018-11</dcterms:issued> <dc:creator>Brunner, Thomas</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42818/1/Hantusch_2-1avtn44ywrh1m6.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:title>Counting on Death : Quantitative aspects of Bcl-2 family regulation</dcterms:title> <dc:contributor>Rehm, Markus</dc:contributor> </rdf:Description> </rdf:RDF>