Working memory task induced neural activation : A simultaneous PET/fMRI study

Ripp, Isabelle; Wallenwein, Lara A.; Wu, Qiong; Emch, Monica; Koch, Kathrin; Cumming, Paul; Yakushev, Igor

Working memory task induced neural activation : A simultaneous PET/fMRI study

Dateien

Ripp_2-1evacymhao8jo3.pdfGröße: 1.43 MBDownloads: 73

Datum

2021

Autor:innen

Ripp, Isabelle

Wallenwein, Lara A.

Wu, Qiong

Emch, Monica

Koch, Kathrin

Cumming, Paul

Yakushev, Igor

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

NeuroImage. Elsevier. 2021, 237, 118131. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2021.118131

Zusammenfassung

Purpose
Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) is a powerful method for mapping cerebral glucose metabolism as a proxy of neural activity, assuming a steady-state during the recording interval. We asked if a clinical FDG-PET imaging protocol might also capture changes in neural activity associated with performance of a working memory (WM) task.

Methods
To test this concept, we examined hybrid PET/MR data for FDG-PET and simultaneous functional magnetic resonance imaging (fMRI) in a sample of healthy volunteers. The PET image acquisition started 30 min after a bolus injection of approximately 100 MBq FDG, and the WM task was undertaken starting at approximately 60 min post-injection. We reconstructed FDG-PET sum images corresponding to baseline (44–60 min p.i.) and WM tasks (63- 71 min p.i.), each with intensity scaling to the corresponding global mean.

Results
Compared to the baseline resting condition, relative FDG uptake increased during WM task performance in brain regions previously associated with WM. Furthermore, these metabolically active regions partly overlapped with the regions showing task-dependent increases in BOLD signal in simultaneous fMRI.

Conclusion
We find evidence for WM task-induced neural activation using a clinical FDG-PET imaging protocol. These findings encourage the development of dedicated protocols for tracking neural correlates of cognitive function.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Cognition, FDG PET, fMRI, Neuroimaging, Positron emission tomography

Zitieren

ISO 690

RIPP, Isabelle, Lara A. WALLENWEIN, Qiong WU, Monica EMCH, Kathrin KOCH, Paul CUMMING, Igor YAKUSHEV, 2021. Working memory task induced neural activation : A simultaneous PET/fMRI study. In: NeuroImage. Elsevier. 2021, 237, 118131. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2021.118131

BibTex

@article{Ripp2021Worki-56611,
  year={2021},
  doi={10.1016/j.neuroimage.2021.118131},
  title={Working memory task induced neural activation : A simultaneous PET/fMRI study},
  volume={237},
  issn={1053-8119},
  journal={NeuroImage},
  author={Ripp, Isabelle and Wallenwein, Lara A. and Wu, Qiong and Emch, Monica and Koch, Kathrin and Cumming, Paul and Yakushev, Igor},
  note={Article Number: 118131}
}

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