Evidence for altered amygdala activation in schizophrenia in an adaptive emotion recognition task

Mier, Daniela; Lis, Stefanie; Zygrodnik, Karina; Sauer, Carina; Ulferts, Jens; Gallhofer, Bernd; Kirsch, Peter

Evidence for altered amygdala activation in schizophrenia in an adaptive emotion recognition task

Dateien

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Datum

2014

Autor:innen

Mier, Daniela

Lis, Stefanie

Zygrodnik, Karina

Sauer, Carina

Ulferts, Jens

Gallhofer, Bernd

Kirsch, Peter

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Psychiatry Research: Neuroimaging. 2014, 221(3), pp. 195-203. ISSN 0925-4927. eISSN 1872-7506. Available under: doi: 10.1016/j.pscychresns.2013.12.001

Zusammenfassung

Deficits in social cognition seem to present an intermediate phenotype for schizophrenia, and are known to be associated with an altered amygdala response to faces. However, current results are heterogeneous with respect to whether this altered amygdala response in schizophrenia is hypoactive or hyperactive in nature. The present study used functional magnetic resonance imaging to investigate emotion-specific amygdala activation in schizophrenia using a novel adaptive emotion recognition paradigm. Participants comprised 11 schizophrenia outpatients and 16 healthy controls who viewed face stimuli expressing emotions of anger, fear, happiness, and disgust, as well as neutral expressions. The adaptive emotion recognition approach allows the assessment of group differences in both emotion recognition performance and associated neuronal activity while also ensuring a comparable number of correctly recognized emotions between groups. Schizophrenia participants were slower and had a negative bias in emotion recognition. In addition, they showed reduced differential activation during recognition of emotional compared with neutral expressions. Correlation analyses revealed an association of a negative bias with amygdala activation for neutral facial expressions that was specific to the patient group. We replicated previous findings of affected emotion recognition in schizophrenia. Furthermore, we demonstrated that altered amygdala activation in the patient group was associated with the occurrence of a negative bias. These results provide further evidence for impaired social cognition in schizophrenia and point to a central role of the amygdala in negative misperceptions of facial stimuli in schizophrenia.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Social cognition, Functional magnetic resonance imaging, Negative bias, Facial affect recognition

Zitieren

ISO 690

MIER, Daniela, Stefanie LIS, Karina ZYGRODNIK, Carina SAUER, Jens ULFERTS, Bernd GALLHOFER, Peter KIRSCH, 2014. Evidence for altered amygdala activation in schizophrenia in an adaptive emotion recognition task. In: Psychiatry Research: Neuroimaging. 2014, 221(3), pp. 195-203. ISSN 0925-4927. eISSN 1872-7506. Available under: doi: 10.1016/j.pscychresns.2013.12.001

BibTex

@article{Mier2014-03-30Evide-45704,
  year={2014},
  doi={10.1016/j.pscychresns.2013.12.001},
  title={Evidence for altered amygdala activation in schizophrenia in an adaptive emotion recognition task},
  number={3},
  volume={221},
  issn={0925-4927},
  journal={Psychiatry Research: Neuroimaging},
  pages={195--203},
  author={Mier, Daniela and Lis, Stefanie and Zygrodnik, Karina and Sauer, Carina and Ulferts, Jens and Gallhofer, Bernd and Kirsch, Peter}
}

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Universitätsbibliographie

Nein

Begutachtet

Ja